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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccne1tm1Jro
targeted mutation 1, James M Roberts
MGI:3584133
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccne1tm1Jro/Ccne1tm1Jro either: 129-Ccne1tm1Jro or B6.129-Ccne1tm1Jro MGI:3586554
hm2
 		Ccne1tm1Jro/Ccne1tm1Jro involves: 129/Sv * 129S4/SvJaeSor MGI:3806610
cx3
 		Ccne1tm1Jro/?
Trp53tm1Tyj/Trp53tm1Tyj 		either: (involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J) or (involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J) MGI:3586556
cx4
 		Ccne1tm1Jro/?
Cdkn1atm1Led/Cdkn1atm1Led 		either: (involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J) or (involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6J) MGI:3586555
cx5
 		Ccne1tm1Jro/?
Krastm3Tyj/? 		either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6) MGI:3586557


Genotype
MGI:3586554
hm1
Allelic
Composition		 Ccne1tm1Jro/Ccne1tm1Jro
Genetic
Background		 either: 129-Ccne1tm1Jro or B6.129-Ccne1tm1Jro
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm1Jro mutation (0 available); any Ccne1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased splenocyte proliferation ( J:99695 )
• a 4-fold increase in the number of proliferating splenocytes is seen
increased spleen weight ( J:99695 )
• spleen weight is 1-2 times that of wild-type
extramedullary hematopoiesis ( J:99695 )
• mild extramedullary hematopoiesis

cellular
abnormal cell physiology ( J:99695 )
• MEFs immortalize earlier than wild-type cells
increased splenocyte proliferation ( J:99695 )
• a 4-fold increase in the number of proliferating splenocytes is seen

immune system
increased splenocyte proliferation ( J:99695 )
• a 4-fold increase in the number of proliferating splenocytes is seen
increased spleen weight ( J:99695 )
• spleen weight is 1-2 times that of wild-type

growth/size/body
increased spleen weight ( J:99695 )
• spleen weight is 1-2 times that of wild-type




Genotype
MGI:3806610
hm2
Allelic
Composition		 Ccne1tm1Jro/Ccne1tm1Jro
Genetic
Background		 involves: 129/Sv * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm1Jro mutation (0 available); any Ccne1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:136692 )
N
• despite in increase in mammary epithelia, mammary gland morphology during pregnancy and involution is normal

digestive/alimentary system
digestive/alimentary phenotype ( J:136692 )
N
• despite in increase in gut epithelia, adult colonic morphology is normal
abnormal intestinal epithelium morphology ( J:136692 )
• gut epithelium exhibits increased proliferation and apoptosis compared to in wild-type mice

endocrine/exocrine glands
increased mammary gland epithelial cell proliferation ( J:136692 )
• mammary epithelium exhibits increased proliferation compared to in wild-type mice
increased mammary gland apoptosis ( J:136692 )
• mammary epithelium exhibits increased apoptosis compared to in wild-type mice

integument
increased mammary gland epithelial cell proliferation ( J:136692 )
• mammary epithelium exhibits increased proliferation compared to in wild-type mice
increased mammary gland apoptosis ( J:136692 )
• mammary epithelium exhibits increased apoptosis compared to in wild-type mice

cellular
increased mammary gland epithelial cell proliferation ( J:136692 )
• mammary epithelium exhibits increased proliferation compared to in wild-type mice




Genotype
MGI:3586556
cx3
Allelic
Composition		 Ccne1tm1Jro/?
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 either: (involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J) or (involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm1Jro mutation (0 available); any Ccne1 mutation (23 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (243 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased fibroblast proliferation ( J:99695 )
• cell proliferation in double mutant MEFs is increased compared to MEFs homozygous null for Trp53 alone

neoplasm
decreased tumor latency ( J:99695 )
• mean tumor-free survival is reduced to 145 days compared to 180 days in mice homozygous null for Trp53 alone




Genotype
MGI:3586555
cx4
Allelic
Composition		 Ccne1tm1Jro/?
Cdkn1atm1Led/Cdkn1atm1Led
Genetic
Background		 either: (involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J) or (involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm1Jro mutation (0 available); any Ccne1 mutation (23 available)
Cdkn1atm1Led mutation (1 available); any Cdkn1a mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell morphology ( J:99695 )
• during a 3T3 immortalization protocol double mutant MEFs display grossly altered cell morphology unlike MEFs homozygous null for Cdkn1a alone
decreased fibroblast proliferation ( J:99695 )
• cell proliferation in double mutant MEFs is reduced compared to MEFs homozygous null for Cdkn1a alone
chromosome breakage ( J:99695 )
• double mutant MEFs have more cells that are tetraploid in early passages and aneuploid in later passages compared to MEFs homozygous null for Cdkn1a alone




Genotype
MGI:3586557
cx5
Allelic
Composition		 Ccne1tm1Jro/?
Krastm3Tyj/?
Genetic
Background		 either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm1Jro mutation (0 available); any Ccne1 mutation (23 available)
Krastm3Tyj mutation (2 available); any Kras mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:99695 )
• mean survival is reduced to 160 days compared to 260 days for mice homozygous for Kras alone

cellular
chromosome breakage ( J:99695 )
• 2 of 6 tumors from double mutants display significant gains or losses of whole chromosomes while no gains or losses of whole chromosomes are seen in Kras homozygotes




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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory