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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl6btm1Dtf
targeted mutation 1, Douglas T Fearson
MGI:3584139
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bcl6btm1Dtf/Bcl6btm1Dtf involves: 129P2/OlaHsd MGI:3716315


Genotype
MGI:3716315
hm1
Allelic
Composition		 Bcl6btm1Dtf/Bcl6btm1Dtf
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6btm1Dtf mutation (0 available); any Bcl6b mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:99818 )
• CD8+ primed cells have impaired proliferation in vitro
decreased memory T cell number ( J:99818 )
• following secondary influenza infection, there is a decreased in the magnitude of the secondary response of the memory Db/NP-specific CD8+ T cells
abnormal response to infection ( J:99818 )
• following secondary influenza infection, there is a decreased in the magnitude of the secondary response of the memory Db/NP-specific CD8+ T cells

hematopoietic system
decreased T cell proliferation ( J:99818 )
• CD8+ primed cells have impaired proliferation in vitro
decreased memory T cell number ( J:99818 )
• following secondary influenza infection, there is a decreased in the magnitude of the secondary response of the memory Db/NP-specific CD8+ T cells

cellular
decreased T cell proliferation ( J:99818 )
• CD8+ primed cells have impaired proliferation in vitro




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory