Phenotypes associated with this allele

• Allele Symbol: Dgki^tm1Mtop
• Allele Name: targeted mutation 1, Matthew K Topham
• Allele ID: MGI:3584141
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dgki^tm1Mtop/Dgki^tm1Mtop	B6.129-Dgki^tm1Mtop	MGI:7294356
hm2	Dgki^tm1Mtop/Dgki^tm1Mtop	involves: 129S1/Sv * 129X1/SvJ	MGI:3589791
cx3	Dgkh^em1Mjz/Dgkh^em1Mjz Dgki^tm1Mtop/Dgki^tm1Mtop	B6.Cg-Dgki^tm1Mtop Dgkh^em1Mjz	MGI:7294358
cx4	Dgki^tm1Mtop/Dgki^tm1Mtop Tg(Hba-x-v-Ha-ras)TG.ACLed/0	involves: 129S1/Sv * 129X1/SvJ * FVB/NTac	MGI:3589794

Genotype
MGI:7294356

hm1

• Allelic Composition: Dgki^tm1Mtop/Dgki^tm1Mtop
• Genetic Background: B6.129-Dgki^tm1Mtop

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:325758 )

♀N • mice exhibit normal acoustic startle response, performance in an elevated plus maze, behavior in an open field test, and sucrose preference

abnormal maternal nurturing ( J:325758 )

♀ • due to deficiency in postnatal care, offspring of mothers exhibit a slightly worse survival within the first two days after birth compared with offspring of wild-type mice

Genotype
MGI:3589791

hm2

• Allelic Composition: Dgki^tm1Mtop/Dgki^tm1Mtop
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

neoplasm

neoplasm ( J:99817 )

N • application of PMA or by full-thickness skin wounding did not cause skin tumors in absence of the v-Ha-ras transgene

N • homozygous mice had a normal gender ratio, were grossly normal

Genotype
MGI:7294358

cx3

• Allelic Composition: Dgkh^em1Mjz/Dgkh^em1Mjz; Dgki^tm1Mtop/Dgki^tm1Mtop
• Genetic Background: B6.Cg-Dgki^tm1Mtop Dgkh^em1Mjz

behavior/neurological

behavior/neurological phenotype ( J:325758 )

♀N • mice exhibit normal acoustic startle response and behavior in an open field test

abnormal sucrose solution preference ( J:325758 )

♀ • female mice exhibit enhanced sucrose preference compared with single homozygotes

increased coping response ( J:325758 )

♀ • female mice exhibit decreased immobility in the forced swim test

increased anxiety-related response ( J:325758 )

♀ • female mice spend more time in the closed arms of an elevated plus maze compared with wild-type mice

hyperactivity ( J:325758 )

♀ • dams that fail to retrieve pups exhibit manic-like exploratory behavior

abnormal sleep pattern ( J:325758 )

♀ • female mice exhibit disrupted sleep patterns with variations in total amount of time spent asleep (longer average wake bout throughout the light phase and shorter first half of the dark phase at ZT12-18) compared with wild-type mice

♀ • however, the average length of individual sleep bouts is normal

abnormal maternal nurturing ( J:325758 )

♀ • due to deficiency in postnatal care, offspring of mothers exhibit decreased survival within the first two days after birth, reduced milk consumption, and slow postnatal weight gain compared with offspring of wild-type mice

♀ • however, pups raised by wild-type dams exhibit normal survival

abnormal pup retrieval ( J:325758 )

♀ • variable

Genotype
MGI:3589794

cx4

• Allelic Composition: Dgki^tm1Mtop/Dgki^tm1Mtop; Tg(Hba-x-v-Ha-ras)TG.ACLed/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NTac

neoplasm

decreased incidence of induced tumors ( J:99817 )

• skin tumors induced by application of PMA or by full-thickness skin wounding are fewer in Dgki^tm1Mtop homozygotes carrying the v-Ha-ras transgene compared to wild-type, transgene-positive mice