Phenotypes associated with this allele

• Allele Symbol: Npb^tm1Ywa
• Allele Name: targeted mutation 1, Masashi Yanagisawa
• Allele ID: MGI:3584339
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Npb^tm1Ywa/Npb^tm1Ywa	involves: 129S6/SvEvTac * C57BL/6J	MGI:3590235
ht2	Npb^tm1Ywa/Npb^+	involves: 129S6/SvEvTac * C57BL/6J	MGI:3590236

Genotype
MGI:3590235

hm1

• Allelic Composition: Npb^tm1Ywa/Npb^tm1Ywa
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

hyperalgesia ( J:99861 )

• response to inflammatory pain but not noninflammatory pain is increased; however anxiety and fear responses and circadian rhythms are normal

growth/size/body

increased body weight ( J:99861 )

• homozygous males, but not females, display increased body weight relative to controls by 30 weeks of age on a low fat diet

Genotype
MGI:3590236

ht2

• Allelic Composition: Npb^tm1Ywa/Npb⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

behavior/neurological

hyperalgesia ( J:99861 )

• response to inflammatory pain but not noninflammatory pain is increased

growth/size/body

increased body weight ( J:99861 )

• heterozygous males display increased body weight relative to controls by 36 weeks of age on a low fat diet