All Phenotypes 7630403G23Rik<Tg(Th-cre)1Tmd> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

7630403G23Rik^{Tg(Th-cre)1Tmd}
transgene insertion 1, Ted M Dawson
MGI:3584380

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ube3a^tm1.1Bdph/Ube3a⁺ 7630403G23Rik^{Tg(Th-cre)1Tmd}/7630403G23Rik⁺	B6.Cg-Ube3a^tm1.1Bdph 7630403G23Rik^{Tg(Th-cre)1Tmd}	MGI:5882094
cn2	Gt(ROSA)26Sor^{tm2(SNCA119)Djmo}/Gt(ROSA)26Sor^{tm2(SNCA119)Djmo} 7630403G23Rik^{Tg(Th-cre)1Tmd}/7630403G23Rik⁺	involves: 129 * C57BL/6	MGI:3851906
cn3	Gt(ROSA)26Sor^{tm1(SNCAA53T)Djmo}/Gt(ROSA)26Sor^{tm1(SNCAA53T)Djmo} 7630403G23Rik^{Tg(Th-cre)1Tmd}/7630403G23Rik⁺	involves: 129 * C57BL/6 * SJL	MGI:4353814
cn4	Gt(ROSA)26Sor^{tm2(SNCA119)Djmo}/Gt(ROSA)26Sor^{tm2(SNCA119)Djmo} 7630403G23Rik^{Tg(Th-cre)1Tmd}/7630403G23Rik⁺	involves: 129 * C57BL/6 * SJL	MGI:4353816
cn5	7630403G23Rik^{Tg(Th-cre)1Tmd}/7630403G23Rik⁺ Trpc5^tm1.1Mfre/Trpc5^tm1.1Mfre	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6N * SJL	MGI:6383672
cn6	Bcl2l1^tm1.1Mam/Bcl2l1^tm1.1Mam 7630403G23Rik^{Tg(Th-cre)1Tmd}/?	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:3586797
cn7	Prlh^tm2Smln/Prlh^tm2Smln 7630403G23Rik^{Tg(Th-cre)1Tmd}/7630403G23Rik⁺	involves: C57BL/6 * C57BL/6J * SJL	MGI:5634287

Allelic Composition	Ube3a^tm1.1Bdph/Ube3a⁺ 7630403G23Rik^{Tg(Th-cre)1Tmd}/7630403G23Rik⁺
Genetic Background	B6.Cg-Ube3a^tm1.1Bdph 7630403G23Rik^{Tg(Th-cre)1Tmd}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
7630403G23Rik^{Tg(Th-cre)1Tmd} mutation (1 available); any 7630403G23Rik mutation (3 available)
Ube3a^tm1.1Bdph mutation (0 available); any Ube3a mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal operant conditioning behavior ( J:235694 )

• when the allele is inherited maternally, mice nose poke more for 30 Hz stimulation than controls, indicating enhanced motivation

nervous system

abnormal GABA-mediated receptor currents ( J:235694 )

• mice with a maternally inherited allele show a greater than 50% reduction in peak amplitude of GABAergic currents relative to controls, while current decay kinetics are normal, indicating decreased GABA co-release

• mice with a maternally inherited allele exhibit diminished GABAergic currents at 30 Hz stimulation of ventral tegmental area-to-nucleus accumbens (VTA-to-NAc) terminals compared to controls

• expression of exogenous vesicular GABA transporter (VGAT) within TH+ terminals normalizes optical intracranial self-stimulation in mice with a maternally inherited allele

• however, no changes in optically evoked dopamine release in TH+ VTA-to-NAc terminals is seen in mice with a maternally inherited allele and mice also exhibit normal glutamatergic co-release with optical stimulation of VTA-to-NAc termimals

Allelic Composition	Gt(ROSA)26Sor^{tm2(SNCA119)Djmo}/Gt(ROSA)26Sor^{tm2(SNCA119)Djmo} 7630403G23Rik^{Tg(Th-cre)1Tmd}/7630403G23Rik⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
7630403G23Rik^{Tg(Th-cre)1Tmd} mutation (1 available); any 7630403G23Rik mutation (3 available)
Gt(ROSA)26Sor^{tm2(SNCA*119)Djmo} mutation (1 available); any Gt(ROSA)26Sor mutation (967 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating noradrenaline level ( J:150777 )

• increased levels of norepinephrine observed in striatum in 10-11 month old mice

decreased dopamine level ( J:150777 )

• 32% reduction in levels of striatal dopamine observed in 10-11 month old mice

increased serotonin level ( J:150777 )

• increased levels of 5-HT observed in prefrontal cortex in 10-11 month old mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 1		DOID:0060367	OMIM:168601	J:150777

Allelic Composition	Gt(ROSA)26Sor^{tm1(SNCAA53T)Djmo}/Gt(ROSA)26Sor^{tm1(SNCAA53T)Djmo} 7630403G23Rik^{Tg(Th-cre)1Tmd}/7630403G23Rik⁺
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
7630403G23Rik^{Tg(Th-cre)1Tmd} mutation (1 available); any 7630403G23Rik mutation (3 available)
Gt(ROSA)26Sor^{tm1(SNCA*A53T)Djmo} mutation (1 available); any Gt(ROSA)26Sor mutation (967 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:150777 )

Allelic Composition	Gt(ROSA)26Sor^{tm2(SNCA119)Djmo}/Gt(ROSA)26Sor^{tm2(SNCA119)Djmo} 7630403G23Rik^{Tg(Th-cre)1Tmd}/7630403G23Rik⁺
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
7630403G23Rik^{Tg(Th-cre)1Tmd} mutation (1 available); any 7630403G23Rik mutation (3 available)
Gt(ROSA)26Sor^{tm2(SNCA*119)Djmo} mutation (1 available); any Gt(ROSA)26Sor mutation (967 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased dopamine level ( J:150777 )

• there are significant reductions in the levels of striatal dopamine (~32%), dihydroxyphenylacetic acid (~46%) and homovanillic acid (~33%) compared to controls at 10-11 months of age

increased noradrenaline level ( J:150777 )

• norepinephrine levels in the striatum are elevated at 10-11 months of age compared to controls

increased serotonin level ( J:150777 )

• 5-HT levels are elevated in the prefrontal cortex at 10-11 months of age compared to controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 1		DOID:0060367	OMIM:168601	J:150777

Allelic Composition	7630403G23Rik^{Tg(Th-cre)1Tmd}/7630403G23Rik⁺ Trpc5^tm1.1Mfre/Trpc5^tm1.1Mfre
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
7630403G23Rik^{Tg(Th-cre)1Tmd} mutation (1 available); any 7630403G23Rik mutation (3 available)
Trpc5^tm1.1Mfre mutation (0 available); any Trpc5 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased ovulation rate ( J:277600 )

prolonged diestrus ( J:277600 )

abnormal estrus ( J:277600 )

• less frequent estrus

prolonged estrous cycle ( J:277600 )

• with irregular reproductive cycle

reduced female fertility ( J:277600 )

• reduced productive matings, number of litters, and litter size

decreased litter size ( J:277600 )

• smaller and fewer liters with increased litter interval

nervous system

abnormal action potential ( J:277600 )

• Th+ ARC neurons exhibit reduced interburst intervals and enhanced instantaneous burst frequencies, increased variability of Vu and reduced burst strength causing a reduction in both depolarization envelope and spike frequency within a burst compared with wild-type cells

• Th+ ARC neurons exhibit loss of prolactin-evoked tonic excitation unlike wild-type mice

• however, rhythmic activity in the presence of prolactin remains intake

homeostasis/metabolism

decreased circulating luteinizing hormone level ( J:277600 )

• some female mice exhibit delayed luteinizing hormone peaks compared with wild-type mice

decreased circulating prolactin level ( J:277600 )

• however, female mice exhibit prolactin surges

Allelic Composition	Bcl2l1^tm1.1Mam/Bcl2l1^tm1.1Mam 7630403G23Rik^{Tg(Th-cre)1Tmd}/?
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
7630403G23Rik^{Tg(Th-cre)1Tmd} mutation (1 available); any 7630403G23Rik mutation (3 available)
Bcl2l1^tm1.1Mam mutation (0 available); any Bcl2l1 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased brain weight ( J:99848 )

• brain weight is 508 +/- 24 mg compared to 571 +/- 8 mg in controls

decreased substantia nigra size ( J:99848 )

• the number of cells is decreased by 25 - 30% and most of the cells lost are tyrosine hydroxylase expressing cells

abnormal locus ceruleus morphology ( J:99848 )

• the number of cells is decreased by 31% and by 27% at 1 and 8-12 months of age, respectively, and most of the cells lost are tyrosine hydroxylase expressing cells

growth/size/body

decreased body weight ( J:99848 )

• body weight is reduced by 18 - 30% compared to control mice lacking the cre transgene

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:99848 )

• mutants are able to stay on an accelerating rotorod significantly longer and at higher velocities

homeostasis/metabolism

decreased dopamine level ( J:99848 )

• striatal dopamine and dopamine metabolite levels are significantly reduced compared to controls

Allelic Composition	Prlh^tm2Smln/Prlh^tm2Smln 7630403G23Rik^{Tg(Th-cre)1Tmd}/7630403G23Rik⁺
Genetic Background	involves: C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
7630403G23Rik^{Tg(Th-cre)1Tmd} mutation (1 available); any 7630403G23Rik mutation (3 available)
Prlh^tm2Smln mutation (0 available); any Prlh mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:215557 )

N	• mice exhibit normal body weight

homeostasis/metabolism

abnormal body temperature homeostasis ( J:215557 )

• mice treated with leptin fails to increase core body temperature unlike wild-type mice

abnormal response/metabolism to endogenous compounds ( J:215557 )

• mice treated with leptin fails to increase core body temperature unlike wild-type mice

• mice treated with leptin fail to exhibit a change in normal, night-time food intake compared with wild-type mice

• however, mice treated with Cck exhibit a suppression in food intake

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