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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rr99tm1Litt
targeted mutation 1, Dan R Littman
MGI:3584476
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rr99tm1Litt/Rr99tm1Litt either: (involves: 129P2/OlaHsd * AKR) or (involves: 129P2/OlaHsd * C57BL/6) MGI:3584481


Genotype
MGI:3584481
hm1
Allelic
Composition
Rr99tm1Litt/Rr99tm1Litt
Genetic
Background
either: (involves: 129P2/OlaHsd * AKR) or (involves: 129P2/OlaHsd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• expression of Cd8 alpha was reduced about 10-20% but numbers and proportions of CD8 (+) T cells in the periphery, lymph nodes and spleen were normal
• gut intraepithelial lymphocyte CD8(+) T cells were significantly reduced

hematopoietic system
• expression of Cd8 alpha was reduced about 10-20% but numbers and proportions of CD8 (+) T cells in the periphery, lymph nodes and spleen were normal
• gut intraepithelial lymphocyte CD8(+) T cells were significantly reduced





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory