Phenotypes associated with this allele

• Allele Symbol: Cd8a^tm1.1Litt
• Allele Name: targeted mutation 1.1, Dan R Littman
• Allele ID: MGI:3584478
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd8a^tm1.1Litt/Cd8a^tm1.1Litt	either: (involves: 129P2/OlaHsd * AKR) or (involves: 129P2/OlaHsd * C57BL/6)	MGI:3584484

Genotype
MGI:3584484

hm1

• Allelic Composition: Cd8a^tm1.1Litt/Cd8a^tm1.1Litt
• Genetic Background: either: (involves: 129P2/OlaHsd * AKR) or (involves: 129P2/OlaHsd * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal CD8-positive, alpha beta T cell morphology ( J:50624 )

• expression of Cd8 alpha was reduced about 10-20% but numbers and proportions of CD8 (+) T cells in the periphery, lymph nodes and spleen were normal

• gut intraepithelial lymphocyte CD8(+) T cells were significantly reduced

hematopoietic system

abnormal CD8-positive, alpha beta T cell morphology ( J:50624 )

• expression of Cd8 alpha was reduced about 10-20% but numbers and proportions of CD8 (+) T cells in the periphery, lymph nodes and spleen were normal

• gut intraepithelial lymphocyte CD8(+) T cells were significantly reduced