All Phenotypes Csf2<tm1Dran> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Csf2^tm1Dran/Csf2^tm1Dran Il3^tm1Glli/Il3^tm1Glli	B6.129S2-Csf2^tm1Dran Il3^tm1Glli	MGI:3586342
cx2	Csf2^tm1Dran/Csf2^tm1Dran Il3^tm1Glli/Il3^tm1Glli	C.129S2-Csf2^tm1Dran Il3^tm1Glli	MGI:3586343
cx3	Csf2^tm1Dran/Csf2^tm1Dran Ifng^tm1Ts/Ifng^tm1Ts Il3^tm1Glli/Il3^tm1Glli	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6	MGI:3586344

Allelic Composition	Csf2^tm1Dran/Csf2^tm1Dran Il3^tm1Glli/Il3^tm1Glli
Genetic Background	B6.129S2-Csf2^tm1Dran Il3^tm1Glli

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf2^tm1Dran mutation (0 available); any Csf2 mutation (35 available)
Il3^tm1Glli mutation (1 available); any Il3 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased eosinophil cell number ( J:67404 )

• increase in circulating eosinophiles but not in bone marrow

abnormal leukocyte physiology ( J:83086 )

• defective phagocytosis of apoptotic cells

decreased susceptibility to type IV hypersensitivity reaction ( J:67404 )

• dramatically reduced response to secondary challenge in tests for contact hypersensitivity

• very reduced cellular infiltrates

• much reduced edema

• very little keratinocyte activation

increased anti-double stranded DNA antibody level ( J:83086 )

• increased level of anti double stranded DNA

glomerulonephritis ( J:83086 )

• appears after 8 months of age

• B and T cell aggregates in the renal pelvis and liver

lung inflammation ( J:67404 )

• extensive lymphoid hyperplasia around both airways and veins

respiratory system

lung inflammation ( J:67404 )

• extensive lymphoid hyperplasia around both airways and veins

abnormal surfactant secretion ( J:83086 )

• accumulation of surfactant in intra-alveolar spaces

renal/urinary system

glomerulonephritis ( J:83086 )

• appears after 8 months of age

• B and T cell aggregates in the renal pelvis and liver

hematopoietic system

increased eosinophil cell number ( J:67404 )

• increase in circulating eosinophiles but not in bone marrow

abnormal leukocyte physiology ( J:83086 )

• defective phagocytosis of apoptotic cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:83086

Allelic Composition	Csf2^tm1Dran/Csf2^tm1Dran Il3^tm1Glli/Il3^tm1Glli
Genetic Background	C.129S2-Csf2^tm1Dran Il3^tm1Glli

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased eosinophil cell number ( J:67404 )

• increase in circulating eosinophiles but not in bone marrow

decreased susceptibility to type IV hypersensitivity reaction ( J:67404 )

• dramatically reduced response to secondary challenge in tests for contact hypersensitivity

• very reduced cellular infiltrates

• much reduced edema

• very little keratinocyte activation

lung inflammation ( J:67404 )

• accumulation of surfactant in intra-alveolar spaces

• extensive lymphoid hyperplasia around both airways and veins

respiratory system

lung inflammation ( J:67404 )

• accumulation of surfactant in intra-alveolar spaces

• extensive lymphoid hyperplasia around both airways and veins

abnormal surfactant secretion ( J:67404 )

• accumulation of surfactant in intra-alveolar spaces

hematopoietic system

increased eosinophil cell number ( J:67404 )

• increase in circulating eosinophiles but not in bone marrow

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:83086 )

• surviving mice became moribund with time

• most died or had to be euthanized before 14 months of age

postnatal lethality, incomplete penetrance ( J:83086 )

• about 40% of homozygotes died of pneumonia in the first few weeks of life

immune system

increased eosinophil cell number ( J:83086 )

• mild eosinophilia in mice surviving beyond the first few weeks of life

increased immunoglobulin level ( J:83086 )

increased IgE level ( J:83086 )

• serum levels increased but not significantly

increased IgG1 level ( J:83086 )

• significantly higher serum IgG1 levels

• non significant increases in serum IgG2b levels

increased inflammatory response ( J:83086 )

• acute and chronic inflammatory reactions found in many organs and tissues

neoplasm

increased B cell derived lymphoma incidence ( J:83086 )

• Lymphoproliferative disease in a high proportion of mice

• develops into B cell lymphomas

increased carcinoma incidence ( J:83086 )

• solid tumors are benign to metastasizing carcinomas

increased ovarian carcinoma incidence ( J:83086 )

• particularly prevalent

hematopoietic system

increased eosinophil cell number ( J:83086 )

• mild eosinophilia in mice surviving beyond the first few weeks of life

increased immunoglobulin level ( J:83086 )

increased IgE level ( J:83086 )

• serum levels increased but not significantly

increased IgG1 level ( J:83086 )

• significantly higher serum IgG1 levels

• non significant increases in serum IgG2b levels

endocrine/exocrine glands

increased ovarian carcinoma incidence ( J:83086 )

• particularly prevalent

reproductive system

increased ovarian carcinoma incidence ( J:83086 )

• particularly prevalent

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	systemic lupus erythematosus	DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:83086

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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