Phenotypes associated with this allele

• Allele Symbol: Ncdn^tm2Afu
• Allele Name: targeted mutation 2, Akiyoshi Fukamizu
• Allele ID: MGI:3586335
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ncdn^tm2Afu/Ncdn^tm2Afu Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:3605043

Genotype
MGI:3605043

cn1

• Allelic Composition: Ncdn^tm2Afu/Ncdn^tm2Afu; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:99914 )

• at 8-10 weeks of age results from both training and probe sessions in a Morris water maze indicate spatial learning is impaired

impaired coordination ( J:99914 )

• at 6 months but not at 2-3 months of age, mutants display impaired performance in both the wire-hanging and rod-walking tests

seizures ( J:99914 )

• at 6 months of age, about 24% of mutants have epileptic seizures frequently observed when mice are placed into a new cage

nervous system

seizures ( J:99914 )

• at 6 months of age, about 24% of mutants have epileptic seizures frequently observed when mice are placed into a new cage

abnormal dentate gyrus morphology ( J:99914 )

• newborn neuroblasts generated from the subgranular zone of the dentate gyrus are increased and increased numbers of reactive astrocyte-like cells are seen in the hilus of the dentate gyrus

abnormal hippocampal mossy fiber morphology ( J:99914 )

• ectopic innervation of mossy fibers into the stratum oriens in the CA3 region is seen

abnormal astrocyte morphology ( J:99914 )

• GFAP- and S100B-expressing cells appear hypertrophic with thick processes from a large cell body