Phenotypes associated with this allele

• Allele Symbol: Tg(Gata1-Zfpm1)1Sho
• Allele Name: transgene insertion 1, Stuart Orkin
• Allele ID: MGI:3586378
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Zfpm1^tm4Sho/Zfpm1^tm4Sho Tg(Gata1-Zfpm1)1Sho/0 Tg(Tek-cre)1Ywa/0	involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL	MGI:3586390
cx2	Tg(Gata1-Zfpm1)1Sho/0 Zfpm1^tm1Sho/Zfpm1^tm1Sho	involves: 129S1/Sv * C57BL/6N * CD-1	MGI:3586383

Genotype
MGI:3586390

cn1

• Allelic Composition: Zfpm1^tm4Sho/Zfpm1^tm4Sho; Tg(Gata1-Zfpm1)1Sho/0; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

thin myocardium ( J:99745 )

• variably thinner than wild type but not as thin as that seen in the Zfpm1 knockout embryos

double outlet right ventricle ( J:99745 )

• observe a small degree of conal rotation, resulting in a slightly more rostral origin of the aorta from the right ventricle compared with that of the pulmonary artery

common atrioventricular valve ( J:99745 )

• have a single common atrioventricular valve

atrial septal defect ( J:99745 )

atrioventricular septal defect ( J:99745 )

ventricular septal defect ( J:99745 )

muscle

thin myocardium ( J:99745 )

• variably thinner than wild type but not as thin as that seen in the Zfpm1 knockout embryos

Genotype
MGI:3586383

cx2

• Allelic Composition: Tg(Gata1-Zfpm1)1Sho/0; Zfpm1^tm1Sho/Zfpm1^tm1Sho
• Genetic Background: involves: 129S1/Sv * C57BL/6N * CD-1

Cardiac defects in Zfpm1^tm1Sho/Zfpm1^tm1Sho Tg(Gata1-Zfpm1)1Sho mice

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:99745 )

• with transgene rescue, embryos die between E14.5 and E15.5 with normal appearing primitive blood cells in the yolk sac and fetal liver

hematopoietic system

hematopoietic system phenotype ( J:99745 )

N • hematopoiesis, definitive erythropoiesis and megakaryopoiesis defects seen in homozygous Zfpm1 mice are rescued by the transgene

cardiovascular system

abnormal heart morphology ( J:99745 )

thin myocardium ( J:99745 )

• myocardium is variably thinner than wild-type but not as thin as in homozygous Zfpm2^tm1Sho mice

double outlet right ventricle ( J:99745 )

common atrioventricular valve ( J:99745 )

• have a single common atrioventricular valve

atrial septal defect ( J:99745 )

atrioventricular septal defect ( J:99745 )

• atrioventricular canal defect

ventricular septal defect ( J:99745 )

hemorrhage ( J:99745 )

homeostasis/metabolism

edema ( J:99745 )

integument

pallor ( J:99745 )

muscle

thin myocardium ( J:99745 )

• myocardium is variably thinner than wild-type but not as thin as in homozygous Zfpm2^tm1Sho mice