All Phenotypes Tg(CAG-cre)1Nagy MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(CAG-cre)1Nagy
transgene insertion 1, Andras Nagy
MGI:3586452

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(CAG-Bgeo,-Tle1,-ALPP)1Lbe/0 Tg(CAG-cre)1Nagy/0	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3697417
cn2	Tg(CAG-Bgeo,-Aes,-ALPP)1Lbe/0 Tg(CAG-cre)1Nagy/0	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3697418
cn3	Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺ Tg(CAG-cre)1Nagy/0 Tg(tetO-Vegfa)90Ala/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR	MGI:3587021
cn4	Ofd1^tm2.1Bfra/Ofd1⁺ Tg(CAG-cre)1Nagy/0	involves: 129S2/SvPas	MGI:3620649
cn5	Ofd1^tm2.1Bfra/Y Tg(CAG-cre)1Nagy/0	involves: 129S2/SvPas	MGI:3620650
cn6	Porcn^tm1.1Jrt/Y Tg(CAG-cre)1Nagy/0	involves: 129S6/SvEvTac * C57BL/6NCr * ICR	MGI:5523428
cn7	Porcn^tm1.1Jrt/Porcn⁺ Tg(CAG-cre)1Nagy/0	involves: 129S6/SvEvTac * C57BL/6NCr * ICR	MGI:5523429
cn8	Stag2^tm1.1Alos/Y Tg(CAG-cre)1Nagy/0	involves: 129S6/SvEvTac * C57BL/6NCrl	MGI:6490364

Allelic Composition	Tg(CAG-Bgeo,-Tle1,-ALPP)1Lbe/0 Tg(CAG-cre)1Nagy/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-Bgeo,-Tle1,-ALPP)1Lbe mutation (1 available)
Tg(CAG-cre)1Nagy mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased lung adenocarcinoma incidence ( J:106684 )

• adults develop lung tumors with 100% penetrance

• neoplasms appear at 1 month resembling noninvasive bronchioalveolar carcinoma; at 3-5 months, visible tumor nodules are noted on the pleural surface with extensive proliferation, but preserving their bronchioalveolar growth pattern

• between 5 and 6 months, number of visible lesions on pleural surface increases from 3.2 to 8.3/mouse

• by 8 months, some lesions appear as whitish solid tumor masses characteristic of invasive cancer; such tumors replace large areas of lung parenchyma and show areas of necrosis

• tumor cells are tall columnar epithelial cells showing a mix of papillary, acinar, as well as bronchioalveolar growth patterns; there is prominent extracellular mucin secretion that causes destruction of alveolar septae

• alveolar and terminal bronchioles are lined with dysplastic epithelial cells with pleomorphic, enlarged ,irregular nuclei

respiratory system

increased lung adenocarcinoma incidence ( J:106684 )

• adults develop lung tumors with 100% penetrance

• between 5 and 6 months, number of visible lesions on pleural surface increases from 3.2 to 8.3/mouse

• by 8 months, some lesions appear as whitish solid tumor masses characteristic of invasive cancer; such tumors replace large areas of lung parenchyma and show areas of necrosis

• alveolar and terminal bronchioles are lined with dysplastic epithelial cells with pleomorphic, enlarged ,irregular nuclei

Allelic Composition	Tg(CAG-Bgeo,-Aes,-ALPP)1Lbe/0 Tg(CAG-cre)1Nagy/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-Bgeo,-Aes,-ALPP)1Lbe mutation (0 available)
Tg(CAG-cre)1Nagy mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:106684 )

• mice are viable and fertile, with no obvious phenotypic abnormalities

Allelic Composition	Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺ Tg(CAG-cre)1Nagy/0 Tg(tetO-Vegfa)90Ala/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy} mutation (5 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(CAG-cre)1Nagy mutation (1 available)
Tg(tetO-Vegfa)90Ala mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:99607 )

• administration of doxycycline in the drinking water to 3-4 month old mice and consequent VEGF-A164 expression in all cell caused death in 3 out of 8 and moribund appearance in rest of animals after 5 days of treatment

embryonic lethality during organogenesis, complete penetrance ( J:99607 )

• administration of doxycycline to pregnant dam starting at day E1.5 and consequent VEGF-A164 expression in all embryonic cell caused lethality at E9.5 with no primitive red blood cells in the developing yolk sac and abnormal blood island

homeostasis/metabolism

edema ( J:99607 )

• administration of doxycycline in the drinking water to 3-4 month old mice and consequent VEGF-A164 expression in all cell caused edema of the face, ears and feet after 2 days of treatment

liver/biliary system

hepatic peliosis ( J:99607 )

• administration of doxycycline in the drinking water to 3-4 month old mice and consequent VEGF-A164 expression in all cell caused "peliosis-like" liver characterized by an extended blood filed enlarged hepatic sinusoids and a total disruption of the normal liver architecture and blood in the intestine after 5 days of treatment

immune system

thymus atrophy ( J:99607 )

• administration of doxycycline in the drinking water to 3-4 month old mice and consequent VEGF-A164 expression in all cell caused a decrease in cellularity and decreased size in thymus after 5 days of treatment

enlarged lymph nodes ( J:99607 )

• administration of doxycycline in the drinking water to 3-4 month old mice and consequent VEGF-A164 expression in all cell caused enlarged lymph nodes after 5 days of treatment

hematopoietic system

thymus atrophy ( J:99607 )

integument

reddish skin ( J:99607 )

• administration of doxycycline in the drinking water to 3-4 month old mice and consequent VEGF-A164 expression in all cell caused erythema of the face, ears and feet after 2 days of treatment

endocrine/exocrine glands

thymus atrophy ( J:99607 )

cardiovascular system

hepatic peliosis ( J:99607 )

Allelic Composition	Ofd1^tm2.1Bfra/Ofd1⁺ Tg(CAG-cre)1Nagy/0
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ofd1^tm2.1Bfra mutation (0 available); any Ofd1 mutation (14 available)
Tg(CAG-cre)1Nagy mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:106035 )

• females die at birth

embryo

embryo phenotype ( J:106035 )

N	• nodal cells have cilia and left-right patterning appears normal

decreased embryo size ( J:106035 )

cardiovascular system

abnormal blood vessel morphology ( J:106035 )

• defects in the great vessels

nervous system

abnormal brain morphology ( J:106035 )

• disorganized

• however, at E9.5 the floor plate is present and at E10.5 development of interneurons and motorneurons appears normal unlike in hemizygous males

renal/urinary system

renal glomerulus cyst ( J:106035 )

• all females have kidney cysts that appear to develop from the glomeruli

• kidney cysts lack the cilia that are normally present in the glomeruli

abnormal renal glomerulus morphology ( J:106035 )

• cystic, but not non-cystic, glomeruli lack cilia

craniofacial

decreased cranium height ( J:106035 )

cleft palate ( J:106035 )

• severe

limbs/digits/tail

polydactyly ( J:106035 )

• 7 to 9 digits

syndactyly ( J:106035 )

short limbs ( J:106035 )

skeleton

decreased cranium height ( J:106035 )

abnormal sternum morphology ( J:106035 )

• not fused along the midline

abnormal rib morphology ( J:106035 )

• rib shape, but not number or position, is abnormal

respiratory system

small lung ( J:106035 )

growth/size/body

cleft palate ( J:106035 )

• severe

decreased embryo size ( J:106035 )

renal glomerulus cyst ( J:106035 )

• all females have kidney cysts that appear to develop from the glomeruli

• kidney cysts lack the cilia that are normally present in the glomeruli

digestive/alimentary system

cleft palate ( J:106035 )

• severe

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
orofaciodigital syndrome I		DOID:0060316	OMIM:311200	J:106035

Allelic Composition	Ofd1^tm2.1Bfra/Y Tg(CAG-cre)1Nagy/0
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ofd1^tm2.1Bfra mutation (0 available); any Ofd1 mutation (14 available)
Tg(CAG-cre)1Nagy mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:106035 )

• the expected number of males are present at E11.5 but the frequency decreases to only 4% by E12.5

embryo

incomplete embryo turning ( J:106035 )

• embryos do not turn

abnormal left-right axis patterning ( J:106035 )

• bilateral expression of normally asymmetric genes (Nodal, Pitx2) is seen

decreased embryo size ( J:106035 )

absent floor plate ( J:106035 )

cardiovascular system

abnormal direction of heart looping ( J:106035 )

• in about 50% the heart tube remains at the midline, in the rest either normal or reversed heart looping is seen

abnormal heart tube morphology ( J:106035 )

• about 50% have a thin, abnormal cardiac tube that remains at the midline

distended pericardium ( J:106035 )

nervous system

abnormal neuron differentiation ( J:106035 )

• at E10.5 no prospective V3 interneurons or motorneurons are detected

absent floor plate ( J:106035 )

growth/size/body

decreased embryo size ( J:106035 )

cellular

abnormal neuron differentiation ( J:106035 )

• at E10.5 no prospective V3 interneurons or motorneurons are detected

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
orofaciodigital syndrome I		DOID:0060316	OMIM:311200	J:106035

Allelic Composition	Porcn^tm1.1Jrt/Y Tg(CAG-cre)1Nagy/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCr * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcn^tm1.1Jrt mutation (1 available); any Porcn mutation (18 available)
Tg(CAG-cre)1Nagy mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:198636 )

• hemizygous males survive to E7.5

embryo

decreased embryo size ( J:198636 )

abnormal extraembryonic tissue morphology ( J:198636 )

absent amnion ( J:198636 )

absent chorion ( J:198636 )

growth/size/body

decreased embryo size ( J:198636 )

Allelic Composition	Porcn^tm1.1Jrt/Porcn⁺ Tg(CAG-cre)1Nagy/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCr * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcn^tm1.1Jrt mutation (1 available); any Porcn mutation (18 available)
Tg(CAG-cre)1Nagy mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:198636 )

• embryos in which the mutant allele is derived from the mother are only recovered to E11.5

embryo

embryo phenotype ( J:198636 )

N	• chorionic plate is normal in E9.5 embryos in which the mutant allele is derived from the mother

abnormal embryo development ( J:198636 )

• embryos described above fail to thrive

abnormal allantois morphology ( J:198636 )

• a ball of allantoic tissue is found at the posterior end of the embryos described above

abnormal placenta morphology ( J:198636 )

• embryos described above fail to establish a functional placenta

abnormal umbilical cord morphology ( J:198636 )

• embryos descrbed above fail to establish a functional umbilical cord

nervous system

nervous system phenotype ( J:198636 )

N	• neural tube closure defects are very rare

Allelic Composition	Stag2^tm1.1Alos/Y Tg(CAG-cre)1Nagy/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stag2^tm1.1Alos mutation (0 available); any Stag2 mutation (15 available)
Tg(CAG-cre)1Nagy mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:298088 )

• mice die between E9.5 and E12.5

cardiovascular system

abnormal cardiac outflow tract development ( J:298088 )

• shortened length and rightward turning at the junction with the ventricular myocardium in mildly affect mice at E9.5

abnormal heart development ( J:298088 )

• distended atria and ventricles at E9.5

• distended OFT and IFT

• severe cardiac anomalies at E10.5 in all mice with extensive necrosis and apoptosis

common atrium ( J:298088 )

decreased heart right ventricle size ( J:298088 )

• in mildly affect mice at E9.5

cellular

decreased cell proliferation ( J:298088 )

• in E9.5 embryos

embryo

embryonic growth retardation ( J:298088 )

• indicated by reduced somite number at E9.5 measuring a day behind

decreased embryo size ( J:298088 )

• mild and severe at E9.5

growth/size/body

embryonic growth retardation ( J:298088 )

• indicated by reduced somite number at E9.5 measuring a day behind

decreased embryo size ( J:298088 )

• mild and severe at E9.5

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