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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Apoa5tm1Hgc
targeted mutation 1, Edward M Rubin
MGI:3586505
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Apoa5tm1Hgc/Apoa5tm1Hgc involves: 129X1/SvJ * C57BL/6 MGI:3609331
ht2
 		Apoa5tm1Hgc/Apoa5+ involves: 129X1/SvJ * C57BL/6 MGI:3609332


Genotype
MGI:3609331
hm1
Allelic
Composition		 Apoa5tm1Hgc/Apoa5tm1Hgc
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoa5tm1Hgc mutation (1 available); any Apoa5 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating triglyceride level ( J:72092 )
• 4x as much plasma triglyceride as wild-type




Genotype
MGI:3609332
ht2
Allelic
Composition		 Apoa5tm1Hgc/Apoa5+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoa5tm1Hgc mutation (1 available); any Apoa5 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating VLDL cholesterol level ( J:72092 )
• VLDL levels are intermediate between homozygotes and wild-type controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory