All Phenotypes Smchd1<MommeD1> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Smchd1^MommeD1
modifiers of murine metastable epiallele D1
MGI:3586547

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smchd1^MommeD1/Smchd1^MommeD1	FVB/NJ-Smchd1^MommeD1	MGI:3607152
hm2	Smchd1^MommeD1/Smchd1^MommeD1	involves: C57BL/6 * FVB/N	MGI:3821573
ht3	Smchd1^MommeD1/Smchd1⁺	FVB/NJ-Smchd1^MommeD1	MGI:3607151
ht4	Smchd1^MommeD1/Smchd1⁺	involves: C57BL/6 * FVB/N	MGI:3821572
ht5	Smchd1^{Gt(AD0165)Wtsi}/Smchd1^MommeD1	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3821574
cx6	A^vy/A Smchd1^MommeD1/Smchd1⁺	involves: C57BL/6J * FVB/NJ	MGI:3607153

Allelic Composition	Smchd1^MommeD1/Smchd1^MommeD1
Genetic Background	FVB/NJ-Smchd1^MommeD1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smchd1^MommeD1 mutation (0 available); any Smchd1 mutation (144 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:99816 )

• female homozygotes die between E10.5 and E14.5, but male homozygotes are viable

cellular

abnormal imprinting ( J:99816 )

• no DNA methylation is detected at the CpG island of Hprt

Allelic Composition	Smchd1^MommeD1/Smchd1^MommeD1
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smchd1^MommeD1 mutation (0 available); any Smchd1 mutation (144 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal maternal decidual layer morphology ( J:142334 )

• decidua of female embryos smaller at E9.5 and E10.5

abnormal trophoblast layer morphology ( J:142334 )

• smaller trophoblast giant cell layer in females

abnormal trophoblast giant cell morphology ( J:142334 )

• nuclei of trophoblast giant cells are markedly smaller than controls

cellular

abnormal DNA methylation ( J:142334 )

• hypomethylation of CpG islands in genes subject to X-inactivation

reproductive system

abnormal maternal decidual layer morphology ( J:142334 )

• decidua of female embryos smaller at E9.5 and E10.5

Allelic Composition	Smchd1^MommeD1/Smchd1⁺
Genetic Background	FVB/NJ-Smchd1^MommeD1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smchd1^MommeD1 mutation (0 available); any Smchd1 mutation (144 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal imprinting ( J:99816 )

• DNA methylation is decreased at the CpG island of Hprt

Allelic Composition	Smchd1^MommeD1/Smchd1⁺
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smchd1^MommeD1 mutation (0 available); any Smchd1 mutation (144 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal DNA methylation ( J:142334 )

• heterozygous female methylation levels are low in embryos but become normal in adults

Allelic Composition	Smchd1^{Gt(AD0165)Wtsi}/Smchd1^MommeD1
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smchd1^{Gt(AD0165)Wtsi} mutation (0 available); any Smchd1 mutation (144 available)
Smchd1^MommeD1 mutation (0 available); any Smchd1 mutation (144 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:142334 )

• no females found at birth

Allelic Composition	A^vy/A Smchd1^MommeD1/Smchd1⁺
Genetic Background	involves: C57BL/6J * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (19 available); any a mutation (463 available)
A^vy mutation (4 available); any a mutation (463 available)
Smchd1^MommeD1 mutation (0 available); any Smchd1 mutation (144 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

yellow coat color ( J:99816 )

• more female pups with yellow coat color are produced when a MommeD1 sire is crossed with a psuedoagouti dam but not when the reciprocal cross is made

integument

yellow coat color ( J:99816 )

• more female pups with yellow coat color are produced when a MommeD1 sire is crossed with a psuedoagouti dam but not when the reciprocal cross is made

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