Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-Tnf)1Brgi
• Allele Name: transgene insertion 1, Brett Giroir
• Allele ID: MGI:3586566
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Irak1^tm1Jth/Irak1^tm1Jth Tg(Myh6-Tnf)1Brgi/?	involves: 129/Sv * C57BL/6J * SJL	MGI:3586620
cx2	Irak1^tm1Jth/Y Tg(Myh6-Tnf)1Brgi/?	involves: 129/Sv * C57BL/6J * SJL	MGI:3586621
tg3	Tg(Myh6-Tnf)1Brgi/?	involves: C57BL/6J * SJL	MGI:3586618

Genotype
MGI:3586620

cx1

• Allelic Composition: Irak1^tm1Jth/Irak1^tm1Jth; Tg(Myh6-Tnf)1Brgi/?
• Genetic Background: involves: 129/Sv * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:84829 )

♀N • mice survived past 150 days of age

cardiovascular system

abnormal heart morphology ( J:84829 )

♀ • only in about 10% of mice, otherwise normal

myocardial fiber degeneration ( J:84829 )

♀ • cardiac myocytes undergoing degenerative changes

myocarditis ( J:84829 )

♀ • diffuse interstitial cellularity

♀ • mononuclear inflammatory cells and fibroblasts

immune system

myocarditis ( J:84829 )

♀ • diffuse interstitial cellularity

♀ • mononuclear inflammatory cells and fibroblasts

muscle

myocardial fiber degeneration ( J:84829 )

♀ • cardiac myocytes undergoing degenerative changes

Genotype
MGI:3586621

cx2

• Allelic Composition: Irak1^tm1Jth/Y; Tg(Myh6-Tnf)1Brgi/?
• Genetic Background: involves: 129/Sv * C57BL/6J * SJL

mortality/aging

mortality/aging ( J:84829 )

♂N • mice survived past 150 days of age

cardiovascular system

abnormal heart morphology ( J:84829 )

♂ • only in about 10% of mice, otherwise normal

myocardial fiber degeneration ( J:84829 )

♂ • cardiac myocytes undergoing degenerative changes

myocarditis ( J:84829 )

♂ • diffuse interstitial cellularity

♂ • mononuclear inflammatory cells and fibroblasts

immune system

myocarditis ( J:84829 )

♂ • diffuse interstitial cellularity

♂ • mononuclear inflammatory cells and fibroblasts

muscle

myocardial fiber degeneration ( J:84829 )

♂ • cardiac myocytes undergoing degenerative changes

Genotype
MGI:3586618

tg3

• Allelic Composition: Tg(Myh6-Tnf)1Brgi/?
• Genetic Background: involves: C57BL/6J * SJL

mortality/aging

premature death ( J:100006 )

• died by 70 days of age

• a few days after the onset of clinical symptoms

cardiovascular system

dilated heart atrium ( J:100006 )

• biatrial

globular heart ( J:100006 )

abnormal heart ventricle morphology ( J:100006 )

• biventricle dilation

cardiac fibrosis ( J:84829 , J:100006 )

• intersitial fibrosis of atria and ventricles (J:84829)

• biventricular fibrosis (J:100006)

decreased heart ventricle muscle contractility ( J:100006 )

• depressed ventricle ejection fraction

myocarditis ( J:84829 , J:100006 )

• mononuclear inflammatory cells and fibroblasts (J:84829)

• diffuse interstitial cellularity (J:84829)

• transmural (J:100006)

behavior/neurological

poor grooming ( J:100006 )

abnormal motor capabilities/coordination/movement ( J:100006 )

hunched posture ( J:100006 )

decreased locomotor activity ( J:100006 )

respiratory system

abnormal respiration ( J:100006 )

• edematous and congested lungs

tachypnea ( J:100006 )

• increased respiration

immune system

myocarditis ( J:84829 , J:100006 )

• mononuclear inflammatory cells and fibroblasts (J:84829)

• diffuse interstitial cellularity (J:84829)

• transmural (J:100006)

homeostasis/metabolism

abnormal atrial thrombosis ( J:100006 )

muscle

decreased heart ventricle muscle contractility ( J:100006 )

• depressed ventricle ejection fraction

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congestive heart failure		DOID:6000		J:100006