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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(HLA-DQA1,HLA-DQB1)1Dv
transgene insertion 1, Chella David
MGI:3586633
Summary 4 genotypes


Genotype
MGI:3623405
cx1
Allelic
Composition		 H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(HLA-DQA1,HLA-DQB1)1Dv/0
Tg(Ins2-CD80)3B7Flv/0
Genetic
Background		 B6.Cg-H2-Ab1b-tm1Gru Tg(HLA-DQA1,HLA-DQB1)1Dv Tg(Ins2-CD80)3B7Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1b-tm1Gru mutation (11 available); any H2-Ab1 mutation (83 available)
Tg(HLA-DQA1,HLA-DQB1)1Dv mutation (3 available)
Tg(Ins2-CD80)3B7Flv mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
salivary gland inflammation ( J:59245 )
• diabetic transgenic mice display sialadenitis
increased susceptibility to autoimmune diabetes ( J:59245 )
• over 80% of transgenic mice develop diabetes (positive urine glucose test and >250 mg/dl blood glucose) beginning at 4 months of age

homeostasis/metabolism
increased circulating glucose level ( J:59245 )
• over 80% have blood glucose levels above 250 mg/dl
increased urine glucose level ( J:59245 )
• seen in over 80% of mice

digestive/alimentary system
salivary gland inflammation ( J:59245 )
• diabetic transgenic mice display sialadenitis

endocrine/exocrine glands
salivary gland inflammation ( J:59245 )
• diabetic transgenic mice display sialadenitis

renal/urinary system
increased urine glucose level ( J:59245 )
• seen in over 80% of mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:59245




Genotype
MGI:3623410
cx2
Allelic
Composition		 Tg(HLA-DQA1,HLA-DQB1)1Dv/0
Tg(Ins2-CD80)3B7Flv/0
Genetic
Background		 B6.Cg-Tg(HLA-DQA1,HLA-DQB1)1Dv Tg(Ins2-CD80)3B7Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(HLA-DQA1,HLA-DQB1)1Dv mutation (3 available)
Tg(Ins2-CD80)3B7Flv mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to autoimmune diabetes ( J:59245 )
• none of the mice develop spontaneous diabetes over the 10-month observation period




Genotype
MGI:3639135
cx3
Allelic
Composition		 H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(HLA-DQA1,HLA-DQB1)1Dv/0
Tg(Ins2-CD80)3B7Flv/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * C57BL/10SnJ * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1b-tm1Gru mutation (11 available); any H2-Ab1 mutation (83 available)
Tg(HLA-DQA1,HLA-DQB1)1Dv mutation (3 available)
Tg(Ins2-CD80)3B7Flv mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased interferon-gamma secretion ( J:68641 )
• stimulated CD4+ T cells secrete increased levels of Ifng compared to either DR4-transgenic or double transgenic MHC class II-deficient mice
decreased interleukin-6 secretion ( J:68641 )
• stimulated CD4+ T cells secrete low levels of Il-6 compared to either DR4-transgenic or double transgenic MHC class II-deficient mice
increased susceptibility to autoimmune diabetes ( J:68641 )
• 73% of mice expressing the transgene develop diabetes (blood glucose >250 mg/dl) compared to 0% of nontransgenic MHC class II-deficient mice

homeostasis/metabolism
increased circulating glucose level ( J:68641 )
• 73% display blood glucose levels above 250 mg/dl
increased urine glucose level ( J:68641 )
• seen in 73% of mice

renal/urinary system
increased urine glucose level ( J:68641 )
• seen in 73% of mice




Genotype
MGI:3639133
cx4
Allelic
Composition		 H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(HLA-DQA1,HLA-DQB1)1Dv/0
Tg(HLA-DRB1)31Dmz/0
Tg(Ins2-CD80)3B7Flv/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * C57BL/10SnJ * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1b-tm1Gru mutation (11 available); any H2-Ab1 mutation (83 available)
Tg(HLA-DQA1,HLA-DQB1)1Dv mutation (3 available)
Tg(HLA-DRB1)31Dmz mutation (1 available)
Tg(Ins2-CD80)3B7Flv mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
salivary gland inflammation ( J:68641 )
• transgenic mice develop sialadenitis and severity is associated with diabetes development
abnormal CD4-positive, alpha beta T cell morphology ( J:68641 )
• coexpression of DR4 and DQ8 transgenes increases CD4+ T cell numbers 2-fold compared to either DR4 or DQ8 single transgenic line
abnormal CD8-positive, alpha beta T cell morphology ( J:68641 )
• there are fewer CD8+ T cells in pancreatic infiltrates than in MHC class II-deficient mice expressing only DQ8
decreased susceptibility to autoimmune diabetes ( J:68641 )
• incidence of diabetes (blood glucose >250 mg/dl; 5/22, 23%) is lowered from incidence in MHC class II-deficient mice expressing the DQ8 transgene (73%) and similar to deficient mice transgenic for DR4

endocrine/exocrine glands
salivary gland inflammation ( J:68641 )
• transgenic mice develop sialadenitis and severity is associated with diabetes development

hematopoietic system
abnormal CD4-positive, alpha beta T cell morphology ( J:68641 )
• coexpression of DR4 and DQ8 transgenes increases CD4+ T cell numbers 2-fold compared to either DR4 or DQ8 single transgenic line
abnormal CD8-positive, alpha beta T cell morphology ( J:68641 )
• there are fewer CD8+ T cells in pancreatic infiltrates than in MHC class II-deficient mice expressing only DQ8

digestive/alimentary system
salivary gland inflammation ( J:68641 )
• transgenic mice develop sialadenitis and severity is associated with diabetes development

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:68641




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory