About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prdm1tm1Masu
targeted mutation 1, M Azim Surani
MGI:3586884
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prdm1tm1Masu/Prdm1tm1Masu involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3590147
ht2
 		Prdm1tm1Masu/Prdm1+ involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3590148


Genotype
MGI:3590147
hm1
Allelic
Composition		 Prdm1tm1Masu/Prdm1tm1Masu
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm1tm1Masu mutation (0 available); any Prdm1 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased primordial germ cell number ( J:99994 )
• at E7.5 primordial germ cell numbers are reduced to at most 5 cells compared to about 25 cells in wild-type mice and tetraploid rescue does not restore the number of primordial germ cells to normal
abnormal primordial germ cell migration ( J:99994 )
• at E7.5 no cells are seen migrating out of the cluster of primordial germ cells and at E8.5 only rare cells appear to be migrating

cellular
decreased primordial germ cell number ( J:99994 )
• at E7.5 primordial germ cell numbers are reduced to at most 5 cells compared to about 25 cells in wild-type mice and tetraploid rescue does not restore the number of primordial germ cells to normal
abnormal primordial germ cell migration ( J:99994 )
• at E7.5 no cells are seen migrating out of the cluster of primordial germ cells and at E8.5 only rare cells appear to be migrating




Genotype
MGI:3590148
ht2
Allelic
Composition		 Prdm1tm1Masu/Prdm1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm1tm1Masu mutation (0 available); any Prdm1 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased primordial germ cell number ( J:99994 )
• at E7.5 primordial germ cell numbers are reduced to about 17.5 cells compared to about 25 cells in wild-type mice; however the cells that are present appear to migrate properly

cellular
decreased primordial germ cell number ( J:99994 )
• at E7.5 primordial germ cell numbers are reduced to about 17.5 cells compared to about 25 cells in wild-type mice; however the cells that are present appear to migrate properly




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory