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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prdm1tm1Masu
targeted mutation 1, M Azim Surani
MGI:3586884
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prdm1tm1Masu/Prdm1tm1Masu involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3590147
ht2
 		Prdm1tm1Masu/Prdm1+ involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3590148


Genotype
MGI:3590147
hm1
Allelic
Composition		 Prdm1tm1Masu/Prdm1tm1Masu
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm1tm1Masu mutation (0 available); any Prdm1 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased primordial germ cell number ( J:99994 )
• at E7.5 primordial germ cell numbers are reduced to at most 5 cells compared to about 25 cells in wild-type mice and tetraploid rescue does not restore the number of primordial germ cells to normal
abnormal primordial germ cell migration ( J:99994 )
• at E7.5 no cells are seen migrating out of the cluster of primordial germ cells and at E8.5 only rare cells appear to be migrating

cellular
decreased primordial germ cell number ( J:99994 )
• at E7.5 primordial germ cell numbers are reduced to at most 5 cells compared to about 25 cells in wild-type mice and tetraploid rescue does not restore the number of primordial germ cells to normal
abnormal primordial germ cell migration ( J:99994 )
• at E7.5 no cells are seen migrating out of the cluster of primordial germ cells and at E8.5 only rare cells appear to be migrating




Genotype
MGI:3590148
ht2
Allelic
Composition		 Prdm1tm1Masu/Prdm1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm1tm1Masu mutation (0 available); any Prdm1 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased primordial germ cell number ( J:99994 )
• at E7.5 primordial germ cell numbers are reduced to about 17.5 cells compared to about 25 cells in wild-type mice; however the cells that are present appear to migrate properly

cellular
decreased primordial germ cell number ( J:99994 )
• at E7.5 primordial germ cell numbers are reduced to about 17.5 cells compared to about 25 cells in wild-type mice; however the cells that are present appear to migrate properly




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory