Phenotypes associated with this allele

• Allele Symbol: Fem1b^tm1Jfma
• Allele Name: targeted mutation 1, Joseph F Maher
• Allele ID: MGI:3586916
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fem1b^tm1Jfma/Fem1b^tm1Jfma	involves: 129X1/SvJ * C57BL/6	MGI:3590085

Genotype
MGI:3590085

hm1

• Allelic Composition: Fem1b^tm1Jfma/Fem1b^tm1Jfma
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased insulin secretion ( J:100017 )

• defective glucose-induced and arginine-induced acute-phase insulin secretion

impaired glucose tolerance ( J:100017 )

• display a hyperglycemic response to the intraperitoneal glucose tolerance test

endocrine/exocrine glands

abnormal pancreatic beta cell physiology ( J:100017 )

• pancreatic insulin content is increased in fasted mice

decreased insulin secretion ( J:100017 )

• defective glucose-induced and arginine-induced acute-phase insulin secretion

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:100017