Phenotypes associated with this allele

• Allele Symbol: Isg15^tm1Kpk
• Allele Name: targeted mutation 1, Klaus-Peter Knobeloch
• Allele ID: MGI:3586990
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Isg15^tm1Kpk/Isg15^tm1Kpk	involves: 129P2/OlaHsd * C57BL/6	MGI:3608119

Genotype
MGI:3608119

hm1

• Allelic Composition: Isg15^tm1Kpk/Isg15^tm1Kpk
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased trabecular bone volume ( J:169924 )

• trabecular bone volume is decreased in 24- and 52-week old mice

decreased compact bone thickness ( J:169924 )

• reduction in cortical thickness of the femur

decreased bone mineralization ( J:169924 )

• isolated bone marrow cells grown in culture exhibit reduced mineralization after differentiation into osteoblasts but normal osteoclastogenesis

decreased bone ossification ( J:169924 )

• decrease in bone formation

• however, osteoclast numbers and their resorptive activity are not affected

decreased bone strength ( J:169924 )

• femurs show decreased biomechanical stability in three point-bending assays

• microcrompression testing shows that force until bone failure is reduced in L6 vertebral bodies

immune system

immune system phenotype ( J:100028 )

N • homozygotes are viable, fertile, and display no abnormalities in the development and distribution of the main cellular components of the immune system, NK cell proliferation or function, and antiviral responses against vesicular stomatitis virus and lymphocytic choriomeningitis virus