Analysis Tools
cellular
azoospermia
(
J:100030
)
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mortality/aging
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• about 70% of homozygotes that survive to birth die within 12 to 24 hours with no milk spot and abnormal breathing
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• about 50% of homozygous embryos die between E10.5 and E12.5
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respiratory system
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• neonates that die shortly after birth have severely shrunken alveoli
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reproductive system
azoospermia
(
J:100030
)
|
|
|
|
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• increased seminal vesicle weight
|
small testis
(
J:100030
)
|
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• round spermatids differentiate to at least step 11 but fail to develop into elongated spermatids and a 6-fold increase in apoptotic germ cells is seen in seminiferous tubule in 12 week old mutants
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• of the about 13% of mice that survive past 2 months, the males, but not females, are infertile
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behavior/neurological
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• some homozygous fail to give vaginal plugs with wild-type females
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hematopoietic system
| N |
• no hematological abnormalities are seen
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growth/size/body
|
• visible at E10.5
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• body weight is increased in 12 week old homozygous males
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endocrine/exocrine glands
|
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• increased seminal vesicle weight
|
small testis
(
J:100030
)
|
|
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embryo
|
• visible at E10.5
|
