All Phenotypes Hivep3<tm1Glm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hivep3^tm1Glm
targeted mutation 1, Laurie H Glimcher
MGI:3586993

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hivep3^tm1Glm/Hivep3^tm1Glm	B6.Cg-Hivep3^tm1Glm	MGI:3628808
hm2	Hivep3^tm1Glm/Hivep3^tm1Glm	involves: 129 * C57BL/6	MGI:3608813
hm3	Hivep3^tm1Glm/Hivep3^tm1Glm	involves: C57BL/6	MGI:5550482
hm4	Hivep3^tm1Glm/Hivep3^tm1Glm	Not Specified	MGI:5550520
ht5	Hivep3^tm1Glm/Hivep3⁺	involves: C57BL/6	MGI:5550480
ht6	Hivep3^tm1Glm/Hivep3^tm2Glm	involves: C57BL/6	MGI:5550481
cn7	Hivep3^tm1Glm/Hivep3^tm1Glm Nfatc1^tm3Glm/Nfatc1^tm3Glm Tg(Mx1-cre)1Cgn/0	involves: C57BL/6 * CBA	MGI:5550521
cx8	Atf4^tm1Tow/Atf4^tm1Tow Hivep3^tm1Glm/Hivep3^tm1Glm	involves: 129 * C57BL/6	MGI:5550513
cx9	Hivep3^tm1Glm/Hivep3^tm1Glm Lrp5^tm3.2Mawa/Lrp5^tm3.2Mawa	involves: 129S1/Sv * C57BL/6	MGI:5550512
cx10	Hivep3^tm1Glm/Hivep3^tm1Glm Runx2^tm1Mjo/Runx2⁺	involves: C57BL/6	MGI:5550514

Allelic Composition	Hivep3^tm1Glm/Hivep3^tm1Glm
Genetic Background	B6.Cg-Hivep3^tm1Glm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hivep3^tm1Glm mutation (0 available); any Hivep3 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal osteoblast physiology ( J:108965 )

• a 5-fold increase in the rate of bone formation is detected; however, osteoblast surface and osteiod thickness are similar to wild-type

• in vitro osteoblasts produce larger and more mineralized nodules but show similar growth curve kinetics to wild-type cells

abnormal bone marrow cavity morphology ( J:108965 )

• long bone marrow cavities are virtually obliterated by 7 months of age

increased bone mass ( J:108965 )

• bone mass is similar at birth but by 8 weeks of age bone mass is increased in the long bones, calvariae, and vertebrae

• however, no premature cartilage mineralization is seen and skeletal morphogenesis is similar to wild-type

osteosclerosis ( J:108965 )

• adult onset

cellular

abnormal osteoblast physiology ( J:108965 )

• a 5-fold increase in the rate of bone formation is detected; however, osteoblast surface and osteiod thickness are similar to wild-type

• in vitro osteoblasts produce larger and more mineralized nodules but show similar growth curve kinetics to wild-type cells

Allelic Composition	Hivep3^tm1Glm/Hivep3^tm1Glm
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hivep3^tm1Glm mutation (0 available); any Hivep3 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased interleukin-2 secretion ( J:100058 )

• CD4 cells activated in vitro by CD3/CD28 stimulation produce 10-fold less IL-2 than wild-type CD4 cells

Allelic Composition	Hivep3^tm1Glm/Hivep3^tm1Glm
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hivep3^tm1Glm mutation (0 available); any Hivep3 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Analysis of bone mass in Lrp5^tm3.2Mawa/Lrp5^tm3.2Mawa, Hivep3^tm1Glm/Hivep3^tm1Glm, and double mutant mice

skeleton

increased bone volume ( J:201597 )

increased compact bone thickness ( J:201597 )

abnormal bone trabecula morphology ( J:201597 )

• decreased trabecula spacing

increased bone trabecula number ( J:201597 )

increased trabecular bone thickness ( J:201597 )

increased bone ossification ( J:201597 )

• increased bone formation rate

Allelic Composition	Hivep3^tm1Glm/Hivep3^tm1Glm
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hivep3^tm1Glm mutation (0 available); any Hivep3 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal osteoclast differentiation ( J:184764 )

• mesenchymal cells are defective in driving osteoclastogenesis

decreased osteoclast cell number ( J:184764 )

• in whole-mount skull preparations and along the surfaces of increased diaphyseal trabecular bone

• however, numbers are normal just below the growth plate

abnormal osteoclast physiology ( J:184764 )

• reduced activity

decreased susceptibility to osteoporosis ( J:184764 )

• due to aging and disuses

• however, bone loss due to secondary hyperparathyroidism is normal

abnormal trabecular bone morphology ( J:184764 )

• increased diaphyseal trabecular bone

decreased bone resorption ( J:184764 )

cellular

abnormal osteoclast differentiation ( J:184764 )

• mesenchymal cells are defective in driving osteoclastogenesis

immune system

abnormal osteoclast differentiation ( J:184764 )

• mesenchymal cells are defective in driving osteoclastogenesis

decreased osteoclast cell number ( J:184764 )

• in whole-mount skull preparations and along the surfaces of increased diaphyseal trabecular bone

• however, numbers are normal just below the growth plate

abnormal osteoclast physiology ( J:184764 )

• reduced activity

hematopoietic system

abnormal osteoclast differentiation ( J:184764 )

• mesenchymal cells are defective in driving osteoclastogenesis

decreased osteoclast cell number ( J:184764 )

• in whole-mount skull preparations and along the surfaces of increased diaphyseal trabecular bone

• however, numbers are normal just below the growth plate

abnormal osteoclast physiology ( J:184764 )

• reduced activity

Allelic Composition	Hivep3^tm1Glm/Hivep3⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hivep3^tm1Glm mutation (0 available); any Hivep3 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Trabecular bone and clavicle analysis in various mice with Runx2^tm1Mjo and/or Hivep3^tm1Glm alleles

skeleton

increased bone volume ( J:201597 )

increased compact bone thickness ( J:201597 )

increased trabecular bone thickness ( J:201597 )

Allelic Composition	Hivep3^tm1Glm/Hivep3^tm2Glm
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hivep3^tm1Glm mutation (0 available); any Hivep3 mutation (104 available)
Hivep3^tm2Glm mutation (0 available); any Hivep3 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Bone phenotype in mice with various combiantions of Hivep3^tm1Glm and/or Hivep3^tm2Glm alleles

skeleton

increased bone volume ( J:201597 )

increased compact bone thickness ( J:201597 )

increased bone trabecula number ( J:201597 )

increased trabecular bone thickness ( J:201597 )

Allelic Composition	Hivep3^tm1Glm/Hivep3^tm1Glm Nfatc1^tm3Glm/Nfatc1^tm3Glm Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hivep3^tm1Glm mutation (0 available); any Hivep3 mutation (104 available)
Nfatc1^tm3Glm mutation (1 available); any Nfatc1 mutation (49 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased bone volume ( J:184764 )

Allelic Composition	Atf4^tm1Tow/Atf4^tm1Tow Hivep3^tm1Glm/Hivep3^tm1Glm
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf4^tm1Tow mutation (1 available); any Atf4 mutation (22 available)
Hivep3^tm1Glm mutation (0 available); any Hivep3 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Bone volume and trabeculae analysis in Hivep3^tm1GlmHivep3^tm1Glm and Atf4^tm1Tow/Atf4^tm1Tow Hivep3^tm1Glm/Hivep3^tm1Glm mice

skeleton

increased bone volume ( J:201597 )

increased trabecular bone thickness ( J:201597 )

increased bone ossification ( J:201597 )

• increased bone formation rate

Allelic Composition	Hivep3^tm1Glm/Hivep3^tm1Glm Lrp5^tm3.2Mawa/Lrp5^tm3.2Mawa
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hivep3^tm1Glm mutation (0 available); any Hivep3 mutation (104 available)
Lrp5^tm3.2Mawa mutation (0 available); any Lrp5 mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Analysis of bone mass in Lrp5^tm3.2Mawa/Lrp5^tm3.2Mawa, Hivep3^tm1Glm/Hivep3^tm1Glm, and double mutant mice

skeleton

increased bone volume ( J:201597 )

• partially rescued from Hivep3^tm1Glm homozygotes

increased compact bone thickness ( J:201597 )

• partially rescued from Hivep3^tm1Glm homozygotes

abnormal bone trabecula morphology ( J:201597 )

• decreased trabecula spacing partially rescued from Hivep3^tm1Glm homozygotes

increased bone trabecula number ( J:201597 )

• partially rescued from Hivep3^tm1Glm homozygotes

increased trabecular bone thickness ( J:201597 )

• partially rescued from Hivep3^tm1Glm homozygotes

increased bone mass ( J:201597 )

• osteosclerotic bone phenotype is partially rescued as in Hivep3^tm1Glm homozygotes

Allelic Composition	Hivep3^tm1Glm/Hivep3^tm1Glm Runx2^tm1Mjo/Runx2⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hivep3^tm1Glm mutation (0 available); any Hivep3 mutation (104 available)
Runx2^tm1Mjo mutation (0 available); any Runx2 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Trabecular bone and clavicle analysis in various mice with Runx2^tm1Mjo and/or Hivep3^tm1Glm alleles

skeleton

clavicle hypoplasia ( J:201597 )

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