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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Klbtm1Yin
targeted mutation 1, Yo-ichi Nabeshima
MGI:3587748
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Klbtm1Yin/Klbtm1Yin involves: C57BL/6 * CBA MGI:3589901


Genotype
MGI:3589901
hm1
Allelic
Composition
Klbtm1Yin/Klbtm1Yin
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klbtm1Yin mutation (1 available); any Klb mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• on an atherogenic diet the gall bladder in homozygotes is smaller
• bile acid synthesis is increased

homeostasis/metabolism
• fecal bile acid excretion is dramatically elevated and the bile acid pool size is slightly increased (only significant in males)
• on an atherogenic diet homozygotes are resistant to gallstone formation

growth/size/body
• slight but significant decrease in body weight

endocrine/exocrine glands
• on an atherogenic diet the gall bladder in homozygotes is smaller





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory