liver/biliary system
• on an atherogenic diet the gall bladder in homozygotes is smaller
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• bile acid synthesis is increased
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homeostasis/metabolism
• fecal bile acid excretion is dramatically elevated and the bile acid pool size is slightly increased (only significant in males)
• on an atherogenic diet homozygotes are resistant to gallstone formation
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growth/size/body
• slight but significant decrease in body weight
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endocrine/exocrine glands
• on an atherogenic diet the gall bladder in homozygotes is smaller
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