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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Myo1atm1Mtys
targeted mutation 1, Matthew J Tyska
MGI:3587749
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Myo1atm1Mtys/Myo1atm1Mtys involves: 129S1/SvImJ MGI:3589900


Genotype
MGI:3589900
hm1
Allelic
Composition		 Myo1atm1Mtys/Myo1atm1Mtys
Genetic
Background		 involves: 129S1/SvImJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo1atm1Mtys mutation (1 available); any Myo1a mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
decreased small intestinal villus size ( J:100193 )
• in the small intestine villus length is slightly but significantly decreased, increased numbers of apoptotic cells are seen at the villus tips and in the lamina propria, and occasional villi with thickened and fractured tips are seen
• under SEM membrane extrusions are seen at the tips of the microvilli, and microvilli packing is loose with gaps between individual microvilli

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:100193 )
N
• hearing and vestibular responses are normal as are activity levels and fertility




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory