Analysis Tools
cardiovascular system
|
• Background Sensitivity: the left umbilical artery occasionally becomes the dominant artery instead of the right one as in controls
|
|
• the right renal artery sometimes lies ventral to the posterior vena cava rather than dorsal to it as in controls
|
digestive/alimentary system
|
• arrangement of the gut is irregular and variable in embryos
|
embryo
|
• Background Sensitivity: the left umbilical artery occasionally becomes the dominant artery instead of the right one as in controls
|
immune system
|
• multiple small giant-cell granulomas are seen on the ventral surface of the central and left lateral lobes of the liver
|
limbs/digits/tail
|
• many E15-E17 embryos have a small papilla on the ulnar side of the fifth digit of the forefoot
|
liver/biliary system
|
• increase in liver lesions
• Background Sensitivity: small umbilical hernia of the liver that occurs posteriorly, between the umbilical arteries and the loop of intestine, in E13.5 embryos
|
renal/urinary system
|
• the right renal artery sometimes lies ventral to the posterior vena cava rather than dorsal to it as in controls
|
hydronephrosis
(
J:5086
)
|
• Background Sensitivity: commonly seen in homozygotes unlike on the SEAC/Gn background
|
hydroureter
(
J:5086
)
|
• Background Sensitivity: commonly seen in homozygotes unlike on the SEAC/Gn background
|
large ureter
(
J:5086
)
|
• the ureters are somewhat larger and slightly irregular in E16.5 embryos
|
reproductive system
| N |
• Background Sensitivity: left gonad displacement is rarely observed unlike on the SEAC/Gn background
|
respiratory system
| N |
• Background Sensitivity: do not develop lung cysts like in the SEAC/Gn background
|
