Phenotypes associated with this allele

• Allele Symbol: Tes^tm1Cro
• Allele Name: targeted mutation 1, Carlo M Croce
• Allele ID: MGI:3587810
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tes^tm1Cro/Tes^tm1Cro	involves: 129X1/SvJ * C57BL/6J	MGI:3589557
ht2	Tes^tm1Cro/Tes^+	involves: 129X1/SvJ * C57BL/6J	MGI:3589558

Genotype
MGI:3589557

hm1

• Allelic Composition: Tes^tm1Cro/Tes^tm1Cro
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Histopathology and cell proliferation in forestomach of Tes^tm1Cro/Tes⁺ and Tes^tm1Cro/Tes^tm1Cro mice on a zinc deficient diet

digestive/alimentary system

small forestomach ( J:100181 )

• the forestomach is smaller than normal and has a very thick epithelium with increased cellular proliferation and the squamous columnar junction is dominated by lesions

• cellular proliferation on a zinc deficient diet is not confined to the basal and suprabasal layers as in wild-type mice but involves deep upward and downward growths as well as focal hyperplastic lesions

abnormal forestomach-glandular stomach junction morphology ( J:100181 )

• the squamo-columnar junction is dominated by lesions

increased stomach tumor incidence ( J:100181 )

• tumor incidence, the number of tumors per mouse, tumor size, and malignancy are increased compared to wild-type mice on a zinc sufficient or deficient diet

• mutants but not wild-type mice develop an array of very large papillomas, dysplasia, in situ carcinomas and squamous cell and adenocarcinomas

neoplasm

increased stomach tumor incidence ( J:100181 )

• tumor incidence, the number of tumors per mouse, tumor size, and malignancy are increased compared to wild-type mice on a zinc sufficient or deficient diet

• mutants but not wild-type mice develop an array of very large papillomas, dysplasia, in situ carcinomas and squamous cell and adenocarcinomas

increased carcinoma incidence ( J:100181 )

• mutants but not wild-type mice developed in situ carcinomas and squamous cell and adenocarcinomas in the forestomach after NMBA treatment on a zinc sufficient or deficient diet

Genotype
MGI:3589558

ht2

• Allelic Composition: Tes^tm1Cro/Tes⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

Histopathology and cell proliferation in forestomach of Tes^tm1Cro/Tes⁺ and Tes^tm1Cro/Tes^tm1Cro mice on a zinc deficient diet

digestive/alimentary system

small forestomach ( J:100181 )

• the forestomach is smaller than normal and has a very thick epithelium with increased cellular proliferation

• cellular proliferation on a zinc deficient diet is not confined to the basal and suprabasal layers as in wild-type mice but involves deep upward and downward growths as well as focal hyperplastic lesions

abnormal forestomach-glandular stomach junction morphology ( J:100181 )

• the squamo-columnar junction is dominated by lesions

increased stomach tumor incidence ( J:100181 )

• tumor incidence, the number of tumors per mouse, tumor size, and malignancy are increased compared to wild-type mice on a zinc sufficient or deficient diet

• mutants but not wild-type mice develop an array of very large papillomas, dysplasia, in situ carcinomas and squamous cell and adenocarcinomas

neoplasm

increased stomach tumor incidence ( J:100181 )

• tumor incidence, the number of tumors per mouse, tumor size, and malignancy are increased compared to wild-type mice on a zinc sufficient or deficient diet

• mutants but not wild-type mice develop an array of very large papillomas, dysplasia, in situ carcinomas and squamous cell and adenocarcinomas

increased carcinoma incidence ( J:100181 )

• mutants but not wild-type mice developed in situ carcinomas and squamous cell and adenocarcinomas in the forestomach after NMBA treatment on a zinc deficient diet

• on a zinc-sufficient diet all of the lesions in the forestomach are benign