All Phenotypes Park7<Gt(XE726)Byg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Park7^Gt(XE726)Byg
gene trap XE726, BayGenomics
MGI:3587946

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Park7^Gt(XE726)Byg/Park7^Gt(XE726)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3793710
cn2	Park7^Gt(XE726)Byg/Park7^Gt(XE726)Byg Pink1^tm1.1Wrst/Pink1^tm1.1Wrst Rrn3^tm1.1Igt/Rrn3^tm1.1Igt Tg(Slc6a3-cre/ERT2)1Span/0	involves: 129 * 129P2/OlaHsd * 129S2/SvPas * C57BL/6J	MGI:6113544
cx3	Park7^Gt(XE726)Byg/Park7^Gt(XE726)Byg Pink1^tm1.1Wrst/Pink1^tm1.1Wrst	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J	MGI:6113417

Allelic Composition	Park7^Gt(XE726)Byg/Park7^Gt(XE726)Byg
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Park7^Gt(XE726)Byg mutation (1 available); any Park7 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased susceptibility to dopaminergic neuron neurotoxicity ( J:134826 )

• mice are more sensitive to dopamine neuron loss induced by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) than wild-type mice

behavior/neurological

abnormal motor coordination/balance ( J:134826 )

• despite normal stride lengths, inverted grid performance and wall time, mice exhibit an increase in the average number of forepaw faults compared to wild-type mice

homeostasis/metabolism

increased susceptibility to dopaminergic neuron neurotoxicity ( J:134826 )

• mice are more sensitive to dopamine neuron loss induced by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) than wild-type mice

abnormal dopamine level ( J:134826 )

• in mice 3 to 4 months old, dopamine transporter uptake is increased 29% compared to in wild-type mice

cellular

increased susceptibility to dopaminergic neuron neurotoxicity ( J:134826 )

• mice are more sensitive to dopamine neuron loss induced by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) than wild-type mice

Allelic Composition	Park7^Gt(XE726)Byg/Park7^Gt(XE726)Byg Pink1^tm1.1Wrst/Pink1^tm1.1Wrst Rrn3^tm1.1Igt/Rrn3^tm1.1Igt Tg(Slc6a3-cre/ERT2)1Span/0
Genetic Background	involves: 129 * 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Park7^Gt(XE726)Byg mutation (1 available); any Park7 mutation (56 available)
Pink1^tm1.1Wrst mutation (0 available); any Pink1 mutation (43 available)
Rrn3^tm1.1Igt mutation (2 available); any Rrn3 mutation (42 available)
Tg(Slc6a3-cre/ERT2)1Span mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal nucleolus morphology ( J:242309 )

• nucleolar integrity is disrupted in dopaminergic neurons of tamoxifen treated mice to a similar level as seen in single conditional Rrn3 mutants

abnormal cell physiology ( J:242309 )

• induction of nucleolar stress is seen in dopaminergic neurons of tamoxifen treated mice to a similar level as seen in single conditional Rrn3 mutants

Allelic Composition	Park7^Gt(XE726)Byg/Park7^Gt(XE726)Byg Pink1^tm1.1Wrst/Pink1^tm1.1Wrst
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:242309 )

N	• mice do not exhibit impaired nucleolar activity in dopaminergic neurons with unaltered rDNA transcription

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