Analysis Tools
homeostasis/metabolism
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• in mice fed a high fat diet and less so when fed a low fat diet, lipid droplets exhibit less association of autophagic vesicles with lipid droplets compared to in control mice
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• mice fed a high fat diet exhibit reduced hepatic glucose production during hyperinsulinemic-euglycemic clamp compared with control mice
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• when fed a high fat diet
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• when fed a high fat diet, mice exhibit impaired insulin responsiveness in liver and adipose tissue compared with control mice
• however, AMPK activation restores insulin sensitivity
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• slightly in lean mice
• substantially in mice fed a high fat diet
• however, hepatic restoration of AMPK restoration reduces triglyceride accumulation in mice fed a high fat diet
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cellular
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• impaired in mice fed a high fat diet
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• in the liver of mice fed a high fat diet
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• in the liver of mice fed a high fat diet
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• in mice fed a high fat diet and less so when fed a low fat diet, lipid droplets exhibit less association of autophagic vesicles with lipid droplets compared to in control mice
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liver/biliary system
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• in the liver of mice fed a high fat diet
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• slightly in lean mice
• substantially in mice fed a high fat diet
• however, hepatic restoration of AMPK restoration reduces triglyceride accumulation in mice fed a high fat diet
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• increased lipid droplets with increased size in mice fed a high fat diet
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adipose tissue
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• impaired in mice fed a high fat diet
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growth/size/body
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• mice fed a high fat diet exhibit normal obesity
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