Analysis Tools|
Allele Symbol Allele Name Allele ID |
Sulf2Gt(PST111)Byg gene trap PST111, BayGenomics MGI:3587954 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice occasionally display partial fusion of sternebra 3 and 4
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• at E18.5, 86% of mice exhibit fusions of sacral vertebra 2 and 42% exhibit more anterior fusions
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• agnathic mice exhibit a narrow craniofacial region
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• in 3 of 126 mice age E14.5 to E18.5
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• in 2 of 126 mice age E14.5 to E18.5
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• agnathic mice exhibit small or absent eyes
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• agnathic mice exhibit small or absent eyes
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• in 3 of 126 mice age E14.5 to E18.5
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• in 2 of 126 mice age E14.5 to E18.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice occasionally display partial fusion of sternebra 3 and 4
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• at P21, 75% of mice exhibit split dorsal vertebrae compared to 22% of wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 11% of mice die between weaning and 6 months of age
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• at P21, mice exhibit a smaller than normal skeleton
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• 5 of 22 mice exhibit incomplete closure of the basisphenoid bone
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• some mice develop misaligned and over-grown incisors unlike in heterozygous mice
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• some mice develop misaligned and over-grown incisors unlike in heterozygous mice
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• 2 of 29 mice exhibit fusion of the anterior tips of the left and right mandible
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• at E16.5, radius length is 89% of double heterozygotes
• at E18.5, the length of the radius is decreased to 93% of double heterozygotes
• at P21, the length of the radius is reduced to 91% of wild-type
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• at E16.5, mice exhibit a decrease in the length of the proliferating zone to 90% of double heterozygotes
• however, the ossified and hypertrophic zones were normal in length and there is no difference in the rate of proliferation within the zone
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• during development mice exhibit a reduction in the number of undifferentiated chondrocytes between sternebra 3 and 4 compared to in double heterozygotes indicating an acceleration of chondrocyte differentiation
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• at E18.5, 85% of mice exhibit small bony bridges to broad connections between 2 or 3 sternebra
• at P0/P1, 100% of mice exhibit different degrees of sternebrae fusion that never involves more than 3 sternebrae
• 94% of mice exhibit fusion of sternebra 3 and 4 (65% complete) and 18% of mice exhibit a fusion of sternebra 2 and 3
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• at E18.5, sternum length is decreased 94% of double heterozygotes
• at P21, sternum length is decreased 87% of wild-type
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• at P21, mice exhibit a broadened sternum compared to in wild-type mice
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• at P21, mice exhibit a small ribcage
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• after P21, 94% of mice exhibit calcified fusion of up to 7 distal tail vertebrae
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• 9 of 29 mice exhibit dorsally malformed second cervical vertebra
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• 3 mice exhibit transformation of C2 into C1
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• at P0/P1, mice exhibit fusion of ossification centers in the lumbar vertebrae
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• at E18.5, 92% of mice exhibit connections in 1 to 5 vertebrae anterior to S2
• at P0/P1, all mice exhibit fusion of ossification centers in the sacral vertebrae
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• at P21, 88% of mice exhibit split dorsal vertebrae compared to 22% of wild-type mice with 47% of mice exhibiting involvement of 2 to 6 vertebrae
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• 5 of 22 mice exhibit incomplete closure of the basisphenoid bone
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• some mice develop misaligned and over-grown incisors unlike in heterozygous mice
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• some mice develop misaligned and over-grown incisors unlike in heterozygous mice
|
|
• 2 of 29 mice exhibit fusion of the anterior tips of the left and right mandible
|
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• some mice develop misaligned and over-grown incisors unlike in heterozygous mice
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• some mice develop misaligned and over-grown incisors unlike in heterozygous mice
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• at P21, occasionally strongly dwarfed mice are observed
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• at P0, body weight is reduced to 91% of double heterozygote weights
• at P21, mice weight 70% of double heterozygotes
• however, surviving mice recover to normal weight during postnatal development
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• at E16.5, radius length is 89% of double heterozygotes
• at E18.5, the length of the radius is decreased to 93% of double heterozygotes
• at P21, the length of the radius is reduced to 91% of wild-type
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• after P21, 94% of mice exhibit calcified fusion of up to 7 distal tail vertebrae
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/09/2024 MGI 6.24 |
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