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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bace1tm1Nn
targeted mutation 1, Nobuyuki Nukina
MGI:3588406
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bace1tm1Nn/Bace1tm1Nn Not Specified MGI:3608125


Genotype
MGI:3608125
hm1
Allelic
Composition		 Bace1tm1Nn/Bace1tm1Nn
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bace1tm1Nn mutation (0 available); any Bace1 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:100272 )
• exhibit impaired processing of the beta subunit of voltage-gated sodium channel (VGSC) as indicated by reduced expression of the C-terminal fragment of VGSC beta in MEFs, cerebrum, and striatum and an increase in the full length VGSC beta in striatum




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory