Phenotypes associated with this allele

• Allele Symbol: Lhx8^tm1Awan
• Allele Name: targeted mutation 1, Akio Wanaka
• Allele ID: MGI:3588411
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lhx8^tm1Awan/Lhx8^tm1Awan	involves: 129S2/SvPas * C57BL/6J	MGI:3590315

Genotype
MGI:3590315

hm1

• Allelic Composition: Lhx8^tm1Awan/Lhx8^tm1Awan
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:100340 )

• most of pups die within several hours of birth with only 14 homozygous pups out of 372 total pups found at weaning

nervous system

abnormal cholinergic neuron morphology ( J:100340 )

• at postnatal day 0 no cholinergic markers are detected in the basal forebrain and in adult homozygotes the number of cholinergic are greatly reduced with the extent of reduction varying between each nucleus; however, GABAergic neurons are normal

craniofacial

cleft palate ( J:100340 )

• about 94% of homozygous pups at birth have a cleft palate

digestive/alimentary system

cleft palate ( J:100340 )

• about 94% of homozygous pups at birth have a cleft palate

growth/size/body

cleft palate ( J:100340 )

• about 94% of homozygous pups at birth have a cleft palate