Phenotypes associated with this allele

• Allele Symbol: Gdf7^tm3(cre)Tmj
• Allele Name: targeted mutation 3, Thomas M Jessell
• Allele ID: MGI:3588567
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gdf7^tm2Tmj/Gdf7^tm3(cre)Tmj	involves: 129S1/Sv	MGI:3590215
cn2	Gdf7^tm3(cre)Tmj/Gdf7^+ Otx2^tm6Asim/Otx2^tm6Asim Tg(CAG-cat,-EGFP)1Rbns/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5473339

Genotype
MGI:3590215

cn1

• Allelic Composition: Gdf7^tm2Tmj/Gdf7^tm3(cre)Tmj
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal choroid plexus morphology ( J:100435 )

• at E14.5 mesencephalic and diencephalic choroid plexus epithelium is reduced and increased apoptosis is seen in the residual diencephalic choroid plexus epithelium; however telencephalic choroid plexus epithelium is well preserved with only a slight reduction in the volume of the anterior domain

• at E16.5 papillary choroid plexus tissue is markedly reduced in the hindbrain and diencephalon

Genotype
MGI:5473339

cn2

• Allelic Composition: Gdf7^tm3(cre)Tmj/Gdf7⁺; Otx2^tm6Asim/Otx2^tm6Asim; Tg(CAG-cat,-EGFP)1Rbns/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

nervous system

abnormal choroid plexus morphology ( J:194049 )

• by E13, a dramatic decrease in hindbrain choroid plexus size is detected relative to controls

• at P2 and adult ages, the choroid plexus is much smaller than in controls

• increased apoptosis (both late and early, overall a 2.5 fold increase) is detected in the hindbrain choroid at E13.5; less proliferating cells are also detected in the plexus compared to controls

• blood vessels form at normal density, although they appear slightly more disorganized in the hindbrain choroid plexus region

abnormal cerebral cortex morphology ( J:194049 )

• at E13, an increase in apical PH3-positive cells is observed (30%) with a slight decrease in basal progenitors (10%); a 40% decrease in PH3-ve cells at the apical surface is detected in the cerebral cortex at P16

abnormal nervous system physiology ( J:194049 )

• total CSF protein concentration is increased by 30% and 60% at E13 and E14 relative to control values; at E12, no change is detected