All Phenotypes Mus81<tm1Chmg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mus81^tm1Chmg
targeted mutation 1, Clare H McGowan
MGI:3588581

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mus81^tm1Chmg/Mus81^tm1Chmg	involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6	MGI:3589458
hm2	Mus81^tm1Chmg/Mus81^tm1Chmg	involves: 129S5/SvEvBrd	MGI:3794047
hm3	Mus81^tm1Chmg/Mus81^tm1Chmg	involves: 129S5/SvEvBrd * C57BL/6	MGI:5559493
cx4	Mus81^tm1Chmg/Mus81^tm1Chmg Slx1b^tm1.1Jrou/Slx1b^tm1.1Jrou	involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6	MGI:5559494
cx5	Fan1^{tm1d(KOMP)Wtsi}/Fan1^{tm1d(KOMP)Wtsi} Mus81^tm1Chmg/Mus81^tm1Chmg	involves: 129S5/SvEvBrd * C57BL/6N * FVB/N	MGI:5897867

Allelic Composition	Mus81^tm1Chmg/Mus81^tm1Chmg
Genetic Background	involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mus81^tm1Chmg mutation (0 available); any Mus81 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:100407 )

• homozygotes display increased sensitivity to mitomycin C-induced lethality but did not display premature aging, decreased life spans, or increased tumor incidence

cellular

decreased cell proliferation ( J:100407 )

• homozygous MEFs die after 3 - 5 days in culture with a significant decrease in cells with 4N DNA and increase in cells with sub-G1 content of DNA after 2 days in culture; however, homozygous mice are viable and display normal growth, immune function, and fertility

• retroviral expression of the viral protein E6 which promotes degradation of Trp53 allows homozygous MEFs to survive in culture although these cells display increased DNA damage and chromosomal aberrations

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:100407 )

• homozygotes display increased sensitivity to mitomycin C-induced lethality but did not display premature aging, decreased life spans, or increased tumor incidence

Allelic Composition	Mus81^tm1Chmg/Mus81^tm1Chmg
Genetic Background	involves: 129S5/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mus81^tm1Chmg mutation (0 available); any Mus81 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:133703 )

N	• unlike mice homozygous for Mus81^tm1Esse, no defects are seen in the aortic wall including the elastin layers

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:232402 )

• MEFs are more sensitive to mitomycin C compared to wild-type cells but less sensitive than MEFs null for Fan1

Allelic Composition	Mus81^tm1Chmg/Mus81^tm1Chmg
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mus81^tm1Chmg mutation (0 available); any Mus81 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased sensitivity to induced cell death ( J:204996 )

• in mouse embryonic fibroblasts treated with DNA interstrand crosslinking agents (MMC)

• however, MMC-induced increase in sister chromatid exchange frequency is normal in mouse embryonic fibroblasts

abnormal DNA repair ( J:204996 )

• Blm-depleted mouse embryonic fibroblasts exhibit reduced sister chromatid exchange frequency compared with wild-type cells

homeostasis/metabolism

abnormal DNA repair ( J:204996 )

• Blm-depleted mouse embryonic fibroblasts exhibit reduced sister chromatid exchange frequency compared with wild-type cells

Allelic Composition	Mus81^tm1Chmg/Mus81^tm1Chmg Slx1b^tm1.1Jrou/Slx1b^tm1.1Jrou
Genetic Background	involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mus81^tm1Chmg mutation (0 available); any Mus81 mutation (31 available)
Slx1b^tm1.1Jrou mutation (0 available); any Slx1b mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:204996 )

N	• mice exhibit normal fertility and testes size

cellular

increased sensitivity to induced cell death ( J:204996 )

• in mouse embryonic fibroblasts treated with DNA interstrand crosslinking agents (MMC) to the same extent as in single homozygotes

• however, MMC-induced increase in sister chromatid exchange frequency is normal in mouse embryonic fibroblasts

abnormal DNA repair ( J:204996 )

• Blm-depleted mouse embryonic fibroblasts exhibit reduced sister chromatid exchange frequency as in single homozygotes

homeostasis/metabolism

abnormal DNA repair ( J:204996 )

• Blm-depleted mouse embryonic fibroblasts exhibit reduced sister chromatid exchange frequency as in single homozygotes

Allelic Composition	Fan1^{tm1d(KOMP)Wtsi}/Fan1^{tm1d(KOMP)Wtsi} Mus81^tm1Chmg/Mus81^tm1Chmg
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6N * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fan1^{tm1d(KOMP)Wtsi} mutation (0 available); any Fan1 mutation (99 available)
Mus81^tm1Chmg mutation (0 available); any Mus81 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:232402 )

• MEFs are as sensitive to mitomycin C as cells from mice homozygous for Fan1 alone

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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