Analysis Tools
growth/size/body
|
• mutant mice are smaller than their unaffected littermates
|
behavior/neurological
limb grasping
(
J:82238
)
|
• from about 3 weeks of age, when lifted by the tail, mutant mice hold their hind limbs close to their bodies; gentle pulling of a hind limb elicits only a slight withdrawal reflex
|
|
• from about 3 weeks of age, mutant mice move slowly and have difficulty maintaining their balance; their hind limbs intermittently lose function and lag behind
|
hematopoietic system
|
• two of six 22 day old mutant mice examined histologically had atrophy of the thymus
|
|
• two of six 22 day old mutant mice examined histologically exhibited hypoplastic bone marrow
|
|
• one of two 22 day old mice (of 6 examined histologically) with bone marrow hypoplasia and thymic atrophy also had diminished red pulp in the spleen
|
immune system
|
• two of six 22 day old mutant mice examined histologically had atrophy of the thymus
|
|
• one of two 22 day old mice (of 6 examined histologically) with bone marrow hypoplasia and thymic atrophy also had diminished red pulp in the spleen
|
endocrine/exocrine glands
|
• two of six 22 day old mutant mice examined histologically had atrophy of the thymus
|
