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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fastm1Ach
targeted mutation 1, Alexander Chervonsky
MGI:3589104
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd19tm1(cre)Cgn/Cd19+
Fastm1Ach/Fastm1Ach 		involves: 129P2/OlaHsd * BALB/c MGI:3720605
cn2
 		Fastm1Ach/Fastm1Ach
Krastm4Tyj/Kras+
Ptentm1Hwu/Ptentm1Hwu 		involves: 129S4/SvJae MGI:5014515
cn3
 		Fastm1Ach/Fastm1Ach
Tg(Lck-cre)548Jxm/? 		involves: C57BL/6 * CBA MGI:3720606
cn4
 		Fastm1Ach/Fastm1Ach
Tg(GZMB-cre)1Jcb/? 		involves: C57BL/6 * FVB/N MGI:3720607
cn5
 		Fastm1Ach/Fastm1Ach
Tg(Itgax-cre,-EGFP)4097Ach/? 		Not Specified MGI:3720730


Genotype
MGI:3720605
cn1
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Fastm1Ach/Fastm1Ach
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Fastm1Ach mutation (0 available); any Fas mutation (82 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enlarged spleen ( J:123556 )
• splenomegaly results from
increased lymphocyte cell number ( J:123556 )
• extensive lympho-proliferation of both T and B cells results in splenomegaly
increased immunoglobulin level ( J:123556 )
• mice have hyperimmunoglobulinemia

hematopoietic system
enlarged spleen ( J:123556 )
• splenomegaly results from
increased lymphocyte cell number ( J:123556 )
• extensive lympho-proliferation of both T and B cells results in splenomegaly
increased immunoglobulin level ( J:123556 )
• mice have hyperimmunoglobulinemia

growth/size/body
enlarged spleen ( J:123556 )
• splenomegaly results from




Genotype
MGI:5014515
cn2
Allelic
Composition		 Fastm1Ach/Fastm1Ach
Krastm4Tyj/Kras+
Ptentm1Hwu/Ptentm1Hwu
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fastm1Ach mutation (0 available); any Fas mutation (82 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased ovarian tumor incidence ( J:161953 )
• triple mutants injected with an adenoviral Cre into the right ovarian bursa to induce recombination are protected from developing ovarian cancer, with only 1 of 11 mice developing cancer compared to 9 of 12 double Kras and Pten mutants

endocrine/exocrine glands
decreased ovarian tumor incidence ( J:161953 )
• triple mutants injected with an adenoviral Cre into the right ovarian bursa to induce recombination are protected from developing ovarian cancer, with only 1 of 11 mice developing cancer compared to 9 of 12 double Kras and Pten mutants

reproductive system
decreased ovarian tumor incidence ( J:161953 )
• triple mutants injected with an adenoviral Cre into the right ovarian bursa to induce recombination are protected from developing ovarian cancer, with only 1 of 11 mice developing cancer compared to 9 of 12 double Kras and Pten mutants




Genotype
MGI:3720606
cn3
Allelic
Composition		 Fastm1Ach/Fastm1Ach
Tg(Lck-cre)548Jxm/?
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fastm1Ach mutation (0 available); any Fas mutation (82 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased double-positive T cell number ( J:123556 )
• CD3+B220+ double positive cells accumulate

hematopoietic system
increased double-positive T cell number ( J:123556 )
• CD3+B220+ double positive cells accumulate




Genotype
MGI:3720607
cn4
Allelic
Composition		 Fastm1Ach/Fastm1Ach
Tg(GZMB-cre)1Jcb/?
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fastm1Ach mutation (0 available); any Fas mutation (82 available)
Tg(GZMB-cre)1Jcb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased double-positive T cell number ( J:123556 )
• CD3+B220+ double positive cells accumulate

hematopoietic system
increased double-positive T cell number ( J:123556 )
• CD3+B220+ double positive cells accumulate




Genotype
MGI:3720730
cn5
Allelic
Composition		 Fastm1Ach/Fastm1Ach
Tg(Itgax-cre,-EGFP)4097Ach/?
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fastm1Ach mutation (0 available); any Fas mutation (82 available)
Tg(Itgax-cre,-EGFP)4097Ach mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased dendritic cell number ( J:123556 )
• dendritic cell number increases with age in the spleen
abnormal spleen morphology ( J:123556 )
• mice exhibit histological changes in the spleen
• loss of follicular architecture is associated with splenomegaly
enlarged spleen ( J:123556 )
• splenomegaly is associated with loss of follicular architecture
abnormal spleen periarteriolar lymphoid sheath morphology ( J:123556 )
• dendritic cells are spread throughout the periarteriolar lymphoid sheath
increased immunoglobulin level ( J:123556 )
• mice have hyperimmunoglobulinemia
increased anti-nuclear antigen antibody level ( J:123556 )
• elevation in anti-nuclear antibodies occurs as early as 8 weeks in some mice and by 12 to 16 weeks in most mice

liver/biliary system
abnormal liver morphology ( J:123556 )
• mice exhibit histological changes in the liver
• polymorphic infiltrate, including Itgax+ dendritic cells and various
• leukocytes, is found around central veins in the liver

cellular
decreased apoptosis ( J:123556 )
• bone marrow dendritic cells are resistant to apoptosis following stimulation with LPS and exposure to CT26 carcinoma cells transfected with human FasL
• splenic dendritic cells are resistant to apoptosis in vivo initiated by cognate OT-1 T cells

hematopoietic system
increased dendritic cell number ( J:123556 )
• dendritic cell number increases with age in the spleen
abnormal spleen morphology ( J:123556 )
• mice exhibit histological changes in the spleen
• loss of follicular architecture is associated with splenomegaly
enlarged spleen ( J:123556 )
• splenomegaly is associated with loss of follicular architecture
abnormal spleen periarteriolar lymphoid sheath morphology ( J:123556 )
• dendritic cells are spread throughout the periarteriolar lymphoid sheath
increased immunoglobulin level ( J:123556 )
• mice have hyperimmunoglobulinemia

growth/size/body
enlarged spleen ( J:123556 )
• splenomegaly is associated with loss of follicular architecture




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory