Phenotypes associated with this allele

• Allele Symbol: Bcl2l11^tm1Sjk
• Allele Name: targeted mutation 1, Stanley J Korsmeyer
• Allele ID: MGI:3589204
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bcl2l11^tm1Sjk/Bcl2l11^tm1Sjk	involves: 129X1/SvJ	MGI:3608662

Genotype
MGI:3608662

hm1

• Allelic Composition: Bcl2l11^tm1Sjk/Bcl2l11^tm1Sjk
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell number ( J:100463 )

• no differences in the number of bone marrow B cells

increased transitional stage B cell number ( J:100463 )

• increase in the number of transitional B cells in the spleen

increased B-2 B cell number ( J:100463 )

• increased number of B-2 cells, but not B-1 cells, from the peritoneal cavity

increased follicular B cell number ( J:100463 )

• increase in the number of follicular B cells in the spleen

abnormal spleen marginal zone morphology ( J:100463 )

• the proportion of marginal zone relative to transitional and follicular B cells is reduced, although the absolute number of marginal zone B cells is normal

abnormal B cell physiology ( J:100463 )

• B cells show partial resistance to apoptotic stimuli, including cytokine withdrawal and BCR crosslinking, but are just as sensitive to VP16 and gamma-irradiation induced cell death as wild-type

increased immunoglobulin level ( J:100463 )

hematopoietic system

increased B cell number ( J:100463 )

• no differences in the number of bone marrow B cells

increased transitional stage B cell number ( J:100463 )

• increase in the number of transitional B cells in the spleen

increased B-2 B cell number ( J:100463 )

• increased number of B-2 cells, but not B-1 cells, from the peritoneal cavity

increased follicular B cell number ( J:100463 )

• increase in the number of follicular B cells in the spleen

abnormal spleen marginal zone morphology ( J:100463 )

• the proportion of marginal zone relative to transitional and follicular B cells is reduced, although the absolute number of marginal zone B cells is normal

abnormal B cell physiology ( J:100463 )

• B cells show partial resistance to apoptotic stimuli, including cytokine withdrawal and BCR crosslinking, but are just as sensitive to VP16 and gamma-irradiation induced cell death as wild-type

increased immunoglobulin level ( J:100463 )