All Phenotypes Rhoc<tm1Mak> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rhoc^tm1Mak/Rhoc^tm1Mak	involves: 129P2/OlaHsd	MGI:3613520
cx2	Rhoc^tm1Mak/Rhoc^tm1Mak Tg(MMTV-PyVT)634Mul/0	involves: 129P2/OlaHsd * FVB/N	MGI:3613521

Allelic Composition	Rhoc^tm1Mak/Rhoc^tm1Mak
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhoc^tm1Mak mutation (1 available); any Rhoc mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:100482 )

N	• no abnormalities in T or B cell numbers or supopoulation ratios are seen • no abnormalities in T or B cell activation are seen • no differences in T cell or thymocyte apoptosis are seen • cell morphology and motility of thymocytes, T cells, B cells and neutrophils are similar to controls

cellular

abnormal cell morphology ( J:100482 )

• fibroblasts from mutant mice exhibit decrease in stress fiber formation in response to serum starvation

• no obvious differences are seen under normal conditions

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:100482 )

• no differences are observed in frequency, size or latency of primary tumor appearance compared to mice carrying only the transgene

• tumor angiogenesis, tumor cell proliferation and apoptosis are likewise similar to mice carrying only the transgene

decreased metastatic potential ( J:100482 )

• significantly reduced numbers of pulmonary metastases are present in the mutant mice

• pulmonary metastases are also reduced in size compared to mice carrying only the transgene

• in vitro, tumor cells derived from mutant mice have reduced migration and invasiveness, and in vivo, metastatic cells appeared to exhibit increased apoptosis

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:100482 )

• no differences are observed in frequency, size or latency of primary tumor appearance compared to mice carrying only the transgene

• tumor angiogenesis, tumor cell proliferation and apoptosis are likewise similar to mice carrying only the transgene

integument

increased mammary adenocarcinoma incidence ( J:100482 )

• no differences are observed in frequency, size or latency of primary tumor appearance compared to mice carrying only the transgene

• tumor angiogenesis, tumor cell proliferation and apoptosis are likewise similar to mice carrying only the transgene

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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