Phenotypes associated with this allele

• Allele Symbol: Peg3^tm1Masu
• Allele Name: targeted mutation 1, M A Surani
• Allele ID: MGI:3589260
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Peg3^tm1Masu/Peg3^+	involves: 129S1/Sv * 129X1/SvJ	MGI:3589808

Genotype
MGI:3589808

ht1

• Allelic Composition: Peg3^tm1Masu/Peg3⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:54324 )

N • normal Fosb expression in the hypothalamic medial preoptic area

abnormal hypothalamus morphology ( J:54324 )

• fewer oxytocin neurons in postpartum heterozygous females

growth/size/body

decreased body weight ( J:54324 )

• pups of heterozygous mothers weigh less than normal likely due to an insufficient oxytocin surge in the heterozygous mother causing, at least, inadequate milk ejection

• after weaning from heterozygous mothers the pups' weight increases but does not entirely catch up with that of pups of +/+ mothers

behavior/neurological

absent maternal crouching ( J:54324 )

♀ • heterozygous mothers take longer to crouch over their pups for feeding and likely have diminished milk ejection

abnormal pup retrieval ( J:54324 )

♀ • heterozygous mothers take longer than wildtype to retrieve pups and re-build nest

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:54324 )

N • histologically normal mammary glands in prepartum and postpartum heterozygotes

cellular

maternal imprinting ( J:54324 )

• expresssion of this allele as assessed by beta-galactosidase staining occurs only in offspring of heterozygous males not heterozygous females

• only the paternal allele is expressed in northern blot analysis at embryonic day 12.5