Phenotypes associated with this allele

• Allele Symbol: Gpx1^tm1Mgr
• Allele Name: targeted mutation 1, Grant R MacGregor
• Allele ID: MGI:3589261
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpx1^tm1Mgr/Gpx1^tm1Mgr	involves: 129 * C57BL/6J	MGI:3589745

Genotype
MGI:3589745

hm1

• Allelic Composition: Gpx1^tm1Mgr/Gpx1^tm1Mgr
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitochondrial physiology ( J:62395 )

• the H₂O₂ reducing Gpx activity is less than 1.5% of normal in liver mitochondria

• the liver mitochondria release H₂O₂ at 4 times the rate of those from wildtype controls, but heart mitochandia show no change in H₂O₂ release

• the mitochondrial respiratory control ratio is reduced and the mitochondrial power output index is decreased in liver but not heart

homeostasis/metabolism

abnormal lipid level ( J:62395 )

• lipid hydroperoxidase levels in total organellar extracts from liver are approximately 60% greater than normal

• lipid hydroperoxidase levels in mitochondrial extracts from liver or heart are not significantly abnormal

• tissue expression of Gpx4 is not upregulated

growth/size/body

decreased body weight ( J:62395 )

• at 8 months of age homozygotes weigh 20% less than +/+ controls

• no differences were detected in liver, kidney, or heart tissue weights compared with +/+ controls