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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gcnt2tm1Tmu
targeted mutation 1, Takashi Muramatsu
MGI:3589370
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gcnt2tm1Tmu/Gcnt2tm1Tmu involves: 129S2/SvPas * C57BL/6 MGI:3603436


Genotype
MGI:3603436
hm1
Allelic
Composition
Gcnt2tm1Tmu/Gcnt2tm1Tmu
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcnt2tm1Tmu mutation (1 available); any Gcnt2 mutation (88 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• significantly reduced spontaneous activity recorded by a computerized activity-tracing chamber
• no motor coordination abnormality were found on rota-rod testing

hematopoietic system
• decrease in the number of lymphocytes caused by the decrease in the number of B cells in both the 2-month-old and the 6-month-old mutant mice

immune system
• decrease in the number of lymphocytes caused by the decrease in the number of B cells in both the 2-month-old and the 6-month-old mutant mice

homeostasis/metabolism

renal/urinary system
• vacuolization in tubular epithelial cells of 8-mont-old mutant mice

integument
• male mutant mice frequently developed epidermoid cysts in the abdominal skin
• until 8 months after birth, the incidence of epidermoid cysts increased to 50%

growth/size/body
• male mutant mice frequently developed epidermoid cysts in the abdominal skin
• until 8 months after birth, the incidence of epidermoid cysts increased to 50%





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory