behavior/neurological
• significantly reduced spontaneous activity recorded by a computerized activity-tracing chamber
• no motor coordination abnormality were found on rota-rod testing
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hematopoietic system
• decrease in the number of lymphocytes caused by the decrease in the number of B cells in both the 2-month-old and the 6-month-old mutant mice
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immune system
• decrease in the number of lymphocytes caused by the decrease in the number of B cells in both the 2-month-old and the 6-month-old mutant mice
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homeostasis/metabolism
renal/urinary system
• vacuolization in tubular epithelial cells of 8-mont-old mutant mice
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integument
• male mutant mice frequently developed epidermoid cysts in the abdominal skin
• until 8 months after birth, the incidence of epidermoid cysts increased to 50%
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growth/size/body
• male mutant mice frequently developed epidermoid cysts in the abdominal skin
• until 8 months after birth, the incidence of epidermoid cysts increased to 50%
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