Phenotypes associated with this allele

• Allele Symbol: Gpx4^tm1Marc
• Allele Name: targeted mutation 1, Marcus Conrad
• Allele ID: MGI:3589378
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpx4^tm1Marc/Gpx4^tm1Marc	involves: 129P2/OlaHsd	MGI:3603211

Genotype
MGI:3603211

hm1

• Allelic Composition: Gpx4^tm1Marc/Gpx4^tm1Marc
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:100525 )

N • mutant mice are viable and fully fertile

N • testis and epididymis morphology and sperm parameter measurements in male mutants are normal

N • toluidine blue and acridine orange stainings of spermatozoa indicated defective chromatin condensation in mutant sperm isolated from the caput epididymis

N • upon drying and hydrating, mutant sperm exhibited morphologically abnormal heads

N • significantly less extensive oxidation in the cauda epididymis when compared to that in the wild-type