Phenotypes associated with this allele

• Allele Symbol: Creb3l4^tm1Imad
• Allele Name: targeted mutation 1, Ibrahim M Adham
• Allele ID: MGI:3589381
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Creb3l4^tm1Imad/Creb3l4^tm1Imad	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3589775

Genotype
MGI:3589775

hm1

• Allelic Composition: Creb3l4^tm1Imad/Creb3l4^tm1Imad
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

oligozoospermia ( J:100527 )

♂ • the number of sperm in the cauda epididymis is only 1.02 x 10⁷ compared to 2.78 x 10⁷ in wild-type mice; however, fertility is not reduced and sperm morphology and motility are normal

multinucleated giant male germ cells ( J:100527 )

♂

abnormal seminiferous tubule morphology ( J:100527 )

♂ • several multinucleated giant cells are present at 3 months of age while these cells are rarely seen in wild-type mice before 6 months of age

♂ • increased numbers of apoptotic cells are seen and these cells are located in the adluminal area rather than near the basement membrane as in wild-type mice

cellular

oligozoospermia ( J:100527 )

♂ • the number of sperm in the cauda epididymis is only 1.02 x 10⁷ compared to 2.78 x 10⁷ in wild-type mice; however, fertility is not reduced and sperm morphology and motility are normal

multinucleated giant male germ cells ( J:100527 )

♂

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:100527 )

♂ • several multinucleated giant cells are present at 3 months of age while these cells are rarely seen in wild-type mice before 6 months of age

♂ • increased numbers of apoptotic cells are seen and these cells are located in the adluminal area rather than near the basement membrane as in wild-type mice