All Phenotypes Caml<tm2Rjb> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Caml^tm1Rjb/Caml^tm2Rjb Tg(Lck-cre)1Cwi/0	involves: 129 * C57BL/6 * DBA/2	MGI:3590220
cn2	Caml^tm1Rjb/Caml^tm2Rjb Tg(Lck-cre)1Cwi/0 Tg(TcraTcrb)1100Mjb/0	involves: 129 * C57BL/6 * DBA/2	MGI:3590221

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased T cell apoptosis ( J:100536 )

• double-positive thymocytes from mutant mice undergo enhanced apoptosis by TCR-stimulation

decreased thymocyte number ( J:100536 )

• the average numbers of total thymocytes were reduced by half

• the number of cells at the double-negative stage was not different

decreased single-positive T cell number ( J:100536 )

• 4- to 6-fold fewer CD4 and CD8 single-positive cells compared to control

• in 3-4 weeks old mutant mice, there were 7- to 9-fold fewer peripheral CD4+ and CD8+ T cells

• in 8-9 weeks old mutant mice, T cell numbers were more similar

immune system

increased T cell apoptosis ( J:100536 )

• double-positive thymocytes from mutant mice undergo enhanced apoptosis by TCR-stimulation

decreased thymocyte number ( J:100536 )

• the average numbers of total thymocytes were reduced by half

• the number of cells at the double-negative stage was not different

decreased single-positive T cell number ( J:100536 )

• 4- to 6-fold fewer CD4 and CD8 single-positive cells compared to control

• in 3-4 weeks old mutant mice, there were 7- to 9-fold fewer peripheral CD4+ and CD8+ T cells

• in 8-9 weeks old mutant mice, T cell numbers were more similar

cellular

increased T cell apoptosis ( J:100536 )

• double-positive thymocytes from mutant mice undergo enhanced apoptosis by TCR-stimulation

endocrine/exocrine glands

decreased thymocyte number ( J:100536 )

• the average numbers of total thymocytes were reduced by half

• the number of cells at the double-negative stage was not different

Allelic Composition	Caml^tm1Rjb/Caml^tm2Rjb Tg(Lck-cre)1Cwi/0 Tg(TcraTcrb)1100Mjb/0
Genetic Background	involves: 129 * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Caml^tm1Rjb mutation (0 available); any Caml mutation (25 available)
Caml^tm2Rjb mutation (0 available); any Caml mutation (25 available)
Tg(Lck-cre)1Cwi mutation (3 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased thymocyte number ( J:100536 )

• reduced numbers of total thymocytes

abnormal negative T cell selection ( J:100536 )

• in an in vitro assay, mutant thymocytes underwent OCA peptide 257-264 dependent cell death more readily than control, indicating enhanced negative selection

abnormal positive T cell selection ( J:100536 )

• lower proportions of double-positive and single-positive cells, and reduced CD8 SP cell in the peripheral T cell population, both indicating impaired positive selection

immune system

decreased thymocyte number ( J:100536 )

• reduced numbers of total thymocytes

abnormal negative T cell selection ( J:100536 )

• in an in vitro assay, mutant thymocytes underwent OCA peptide 257-264 dependent cell death more readily than control, indicating enhanced negative selection

abnormal positive T cell selection ( J:100536 )

• lower proportions of double-positive and single-positive cells, and reduced CD8 SP cell in the peripheral T cell population, both indicating impaired positive selection

endocrine/exocrine glands

decreased thymocyte number ( J:100536 )

• reduced numbers of total thymocytes

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