Phenotypes associated with this allele

• Allele Symbol: Rigi^tm1Aki
• Allele Name: targeted mutation 1, Shizuo Akira
• Allele ID: MGI:3589395
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rigi^tm1Aki/Rigi^tm1Aki	involves: 129/Sv * C57BL/6	MGI:3803344
hm2	Rigi^tm1Aki/Rigi^tm1Aki	involves: 129/Sv * C57BL/6 * ICR	MGI:3803345
hm3	Rigi^tm1Aki/Rigi^tm1Aki	Not Specified	MGI:3590133
cx4	Rigi^tm1Aki/Rigi^tm1Aki Ifih1^tm1Aki/Ifih1^tm1Aki	involves: 129/Sv * C57BL/6	MGI:3803343
cx5	Rigi^tm1Aki/Rigi^tm1Aki Tnf^tm1Sek/Tnf^tm1Sek	involves: C57BL/6 * CBA	MGI:3590134

Genotype
MGI:3803344

hm1

• Allelic Composition: Rigi^tm1Aki/Rigi^tm1Aki
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:137522 )

• impaired production of interferon beta in MEFs stimulated with dsRNA or Japanese encephalitis virus

• severely impaired production of type-I interferons in MEFs in response to mutant negative-sense ssRNA viruses lacking viral proteins that suppress interferon expression

• however, production of interferon beta in response to poly(I:C) is similar to controls

immune system

abnormal dendritic cell physiology ( J:137522 )

• impaired production of interferon beta in response to Sendai virus in bone marrow derived dendritic cells

Genotype
MGI:3803345

hm2

• Allelic Composition: Rigi^tm1Aki/Rigi^tm1Aki
• Genetic Background: involves: 129/Sv * C57BL/6 * ICR

mortality/aging

increased susceptibility to Flaviviridae infection induced morbidity/mortality ( J:137522 )

• more susceptible to Japanese encephalitis virus and vesicular stomatitis virus induced lethality

• but susceptibility to encephalomyocarditis virus is similar to controls

decreased survivor rate ( J:137522 )

• Background Sensitivity: when heterozygotes on a mixed ICR background are crossed some homozygous mice survive to adulthood but the numbers are about half that of wild-type littermates

immune system

abnormal interferon level ( J:137522 )

• markedly decreased serum interferon alpha level following infection with Japanese encephalitis virus

increased susceptibility to Flaviviridae infection induced morbidity/mortality ( J:137522 )

• more susceptible to Japanese encephalitis virus and vesicular stomatitis virus induced lethality

• but susceptibility to encephalomyocarditis virus is similar to controls

homeostasis/metabolism

abnormal interferon level ( J:137522 )

• markedly decreased serum interferon alpha level following infection with Japanese encephalitis virus

Genotype
MGI:3590133

hm3

• Allelic Composition: Rigi^tm1Aki/Rigi^tm1Aki
• Genetic Background: Not Specified

mortality/aging

postnatal lethality, complete penetrance ( J:100539 )

• a few mice were born alive, but showed growth retardation and died within 3 weeks after birth

embryonic lethality during organogenesis, incomplete penetrance ( J:100539 )

• most homozygous embryos were dead at embryonic days 12.5 to 14.0

liver/biliary system

liver degeneration ( J:100539 )

• histological analysis of embryonic day 12.5 embryos revealed massive liver degeneration accompanied with aberrant occurrence of apoptosis

Genotype
MGI:3803343

cx4

• Allelic Composition: Rigi^tm1Aki/Rigi^tm1Aki; Ifih1^tm1Aki/Ifih1^tm1Aki
• Genetic Background: involves: 129/Sv * C57BL/6

cellular

abnormal cell physiology ( J:137522 )

• complete loss of interferon beta production in response to Sendai virus (with a mutated C protein) or encephalomyocarditis virus

Genotype
MGI:3590134

cx5

• Allelic Composition: Rigi^tm1Aki/Rigi^tm1Aki; Tnf^tm1Sek/Tnf^tm1Sek
• Genetic Background: involves: C57BL/6 * CBA

mortality/aging

postnatal lethality ( J:100539 )

• only 1 double homozygous viable pup out of 43 pups born from intercrossing Ddx58^tm1Aki heterozygous and Tnf^tm1Sek homozygous mice

• specific time of death was not reported

• lethality is similar to Ddx58^tm1Aki heterozygous mice and no rescue was observed