Analysis Tools
hematopoietic system
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• thymocytes from mutant mice shows enhanced apoptosis to TCR/CD3 and Fas stimulation
• without stimulation, three- to fourfold increases of apoptotic cells in freshly isolated CD4+ and CD8+ single-positive thymocytes over the control cells (there was no such increase for mutant double-positive cells)
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• total thymocyte numbers were not significantly different from wild-type
• in 3-5 weeks old mice the percentages of CD4+ and CD8+ single-positive thymocytes were reduced by 50-70%
• the numbers of CD4+ and CD8+ T lymphocytes in peripheral blood, spleen and lymph nodes were significantly reduced
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immune system
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• thymocytes from mutant mice shows enhanced apoptosis to TCR/CD3 and Fas stimulation
• without stimulation, three- to fourfold increases of apoptotic cells in freshly isolated CD4+ and CD8+ single-positive thymocytes over the control cells (there was no such increase for mutant double-positive cells)
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• total thymocyte numbers were not significantly different from wild-type
• in 3-5 weeks old mice the percentages of CD4+ and CD8+ single-positive thymocytes were reduced by 50-70%
• the numbers of CD4+ and CD8+ T lymphocytes in peripheral blood, spleen and lymph nodes were significantly reduced
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cellular
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• thymocytes from mutant mice shows enhanced apoptosis to TCR/CD3 and Fas stimulation
• without stimulation, three- to fourfold increases of apoptotic cells in freshly isolated CD4+ and CD8+ single-positive thymocytes over the control cells (there was no such increase for mutant double-positive cells)
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endocrine/exocrine glands
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• thymocytes from mutant mice shows enhanced apoptosis to TCR/CD3 and Fas stimulation
• without stimulation, three- to fourfold increases of apoptotic cells in freshly isolated CD4+ and CD8+ single-positive thymocytes over the control cells (there was no such increase for mutant double-positive cells)
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