Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ndel1tm1.1Shr targeted mutation 1.1, Shinji Hirotsune MGI:3589465 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygous embryos are present at E3.5 but absent at E5.5
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• in blastocyst cultures the inner cell mass grows poorly and degenerates shortly after 3 days in culture
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• dendritic extensions of postmiotic neurons in the cortical plate are irregular and fragmented
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• mild partial splitting and diffuse pyramidal cells are seen in the CA3 and CA2 regions of the hippocampus
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E15.5, but not at E11.5, increased apoptosis is seen in the ventricular zone
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• migration defects in the hippocampus are slightly more severe than in Pafah1b1 single heterozygotes with the number of cells the reached layer II now reduced
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• dendritic extensions of postmiotic neurons in the cortical plate are irregular and fragmented
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• a mild reduction in the number of cells in the neocortex is seen with preferential loss of later migrating cells
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• at E15.5, but not at E11.5, increased apoptosis is seen in the ventricular zone
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• migration defects in the hippocampus are slightly more severe than in Pafah1b1 single heterozygotes with the number of cells the reached layer II now reduced
|
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• dendritic extensions of postmiotic neurons in the cortical plate are irregular and fragmented
|
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• partial splitting of the pyramidal cells in the CA3 regions of the hippocampus is seen unlike in either single heterozygote
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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