Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm2(Wnt1/GFP)Amc}
• Allele Name: targeted mutation 2, Andrew P McMahon
• Allele ID: MGI:3589804
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor^+ Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2^+ Tg(Tcfap2a-cre)1Will/0	involves: 129P2/OlaHsd * 129S/Sv * 129X1/SvJ	MGI:5305934
cn2	Gt(ROSA)26Sor^tm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor^+ Tg(Hoxb7-cre)13Amc/0 Wnt9b^tm1.1Amc/Wnt9b^tm1.1Amc	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:3716215
cx3	Gt(ROSA)26Sor^tm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor^+ Wnt9b^tm1.1Amc/Wnt9b^tm1.1Amc	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:3716214

Genotype
MGI:5305934

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm2(Wnt1/GFP)Amc}/Gt(ROSA)26Sor⁺; Pbx1^tm1Koss/Pbx1^tm1Koss; Pbx2^tm1Mlc/Pbx2⁺; Tg(Tcfap2a-cre)1Will/0
• Genetic Background: involves: 129P2/OlaHsd * 129S/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

craniofacial phenotype ( J:178316 )

N • the cleft lip phenotype observed in Pbx1^tm1.1Koss/Pbx1^tm1.1Koss Pbx2^tm1Mlc/Pbx2⁺ Tg(Tcfap2a*-cre)1Will is rescued

Genotype
MGI:3716215

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm2(Wnt1/GFP)Amc}/Gt(ROSA)26Sor⁺; Tg(Hoxb7-cre)13Amc/0; Wnt9b^tm1.1Amc/Wnt9b^tm1.1Amc
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

renal/urinary system

renal/urinary system phenotype ( J:100575 )

N • when the Wnt1:GFP fusion protein is expressed in the Wolffian duct, embryos exhibit normal mesonephric and metanephric tubule induction, as well as caudal extension of the Mullerian duct

Genotype
MGI:3716214

cx3

• Allelic Composition: Gt(ROSA)26Sor^{tm2(Wnt1/GFP)Amc}/Gt(ROSA)26Sor⁺; Wnt9b^tm1.1Amc/Wnt9b^tm1.1Amc
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

mortality/aging

neonatal lethality ( J:100575 )

• phenotype is stated to be identical to that of Wnt9b^tm1.1Amc homozygotes; however only limited data is presented

renal/urinary system

abnormal kidney collecting duct morphology ( J:100575 )

abnormal kidney development ( J:100575 )

• no pretubular aggregates are apparent

embryo

abnormal Mullerian duct morphology ( J:100575 )

• development is arrested