Phenotypes associated with this allele

• Allele Symbol: Dcstamp^tm1Suda
• Allele Name: targeted mutation 1, Toshio Suda
• Allele ID: MGI:3589828
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dcstamp^tm1Suda/Dcstamp^tm1Suda	Not Specified	MGI:3590210

Genotype
MGI:3590210

hm1

• Allelic Composition: Dcstamp^tm1Suda/Dcstamp^tm1Suda
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoclast differentiation ( J:100555 )

• mononuclear osteoclasts are present but these cells fail to fuse to form multinuclear osteoclasts

• in mixed cultures of homozygous and wild-type cells mutant osteoclasts fuse with wild-type cells to form multinuclear cells

abnormal osteoclast physiology ( J:100555 )

• bone resorbtion is reduced even when a similar number of nuclei are present

increased bone mineral density ( J:100555 )

increased bone mass ( J:100555 )

• bone volume per tissue is increased

increased trabecular bone mass ( J:100555 )

• trabecular bone mass is increased

osteopetrosis ( J:100555 )

• mild osteopetrosis is seen; however, tooth eruption and formation of the bone marrow cavity are normal

immune system

abnormal osteoclast differentiation ( J:100555 )

• mononuclear osteoclasts are present but these cells fail to fuse to form multinuclear osteoclasts

• in mixed cultures of homozygous and wild-type cells mutant osteoclasts fuse with wild-type cells to form multinuclear cells

abnormal macrophage physiology ( J:100555 )

• formation of foreign body giant cells is inhibited

abnormal osteoclast physiology ( J:100555 )

• bone resorbtion is reduced even when a similar number of nuclei are present

hematopoietic system

abnormal osteoclast differentiation ( J:100555 )

• mononuclear osteoclasts are present but these cells fail to fuse to form multinuclear osteoclasts

• in mixed cultures of homozygous and wild-type cells mutant osteoclasts fuse with wild-type cells to form multinuclear cells

abnormal macrophage physiology ( J:100555 )

• formation of foreign body giant cells is inhibited

abnormal osteoclast physiology ( J:100555 )

• bone resorbtion is reduced even when a similar number of nuclei are present

cellular

abnormal osteoclast differentiation ( J:100555 )

• mononuclear osteoclasts are present but these cells fail to fuse to form multinuclear osteoclasts

• in mixed cultures of homozygous and wild-type cells mutant osteoclasts fuse with wild-type cells to form multinuclear cells