About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp53tm1Thl
targeted mutation 1, Thomas Ludwig
MGI:3589921
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ptentm2.1Ppp/Ptentm2.1Ppp
Trp53tm1Thl/Trp53tm1Thl
Tg(Pbsn-cre)4Prb/0 		involves: 129S1/Sv * C57BL/6 * DBA/2 MGI:3603330
cn2
 		Brca1tm1Thl/Brca1tm1Thl
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:5494464
cn3
 		Brca1tm1Thl/Brca1tm2Rjbr
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:5494465
cn4
 		Brca1tm1Thl/Brca1tm3.1Rjbr
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:5494462
cn5
 		Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0 		involves: 129S4/SvJae * FVB/N MGI:5494463
cn6
 		Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
Trp53tm1Thl/Trp53tm1Thl
Tyrc-Brd/Tyrc-Brd 		involves: 129/Sv * 129S4/SvJae * C57BL/6 MGI:5008634
cn7
 		Trp53tm1Thl/Trp53tm1Thl
Tg(Pbsn-cre)4Prb/0 		involves: C57BL/6 * DBA/2 MGI:3603329
cn8
 		Huwe1tm1Wgu/Y
Tg(Ins2-cre)23Herr/0
Trp53tm1Thl/Trp53tm1Thl 		involves: C57BL/6J * CBA/J MGI:5315853


Genotype
MGI:3603330
cn1
Allelic
Composition		 Ptentm2.1Ppp/Ptentm2.1Ppp
Trp53tm1Thl/Trp53tm1Thl
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm2.1Ppp mutation (0 available); any Pten mutation (88 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:100683 )
• all mutants died by 7 months of age

neoplasm
increased prostate gland tumor incidence ( J:100683 )
• invasive prostatic cancer is seen in all mutants by 10 weeks of age
• average tumor weight is increased 32-fold compared to mutants wild-type for Trp53 and these tumors encompass the entire genitourinary tract and pelvis
• no increase is seen in the number of senescent cells compared to wild-type prostates unlike in mutants wild-type for Trp53
increased carcinoma incidence ( J:100683 )
• by 11 weeks of age invasive adenocarcinoma develops

renal/urinary system
urinary bladder obstruction ( J:100683 )
• bladder obstruction

reproductive system
increased prostate gland tumor incidence ( J:100683 )
• invasive prostatic cancer is seen in all mutants by 10 weeks of age
• average tumor weight is increased 32-fold compared to mutants wild-type for Trp53 and these tumors encompass the entire genitourinary tract and pelvis
• no increase is seen in the number of senescent cells compared to wild-type prostates unlike in mutants wild-type for Trp53

endocrine/exocrine glands
increased prostate gland tumor incidence ( J:100683 )
• invasive prostatic cancer is seen in all mutants by 10 weeks of age
• average tumor weight is increased 32-fold compared to mutants wild-type for Trp53 and these tumors encompass the entire genitourinary tract and pelvis
• no increase is seen in the number of senescent cells compared to wild-type prostates unlike in mutants wild-type for Trp53




Genotype
MGI:5494464
cn2
Allelic
Composition		 Brca1tm1Thl/Brca1tm1Thl
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Thl mutation (1 available); any Brca1 mutation (114 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor latency ( J:177853 )
• mice succumb to pancreatic tumors with an average latency of 68 days




Genotype
MGI:5494465
cn3
Allelic
Composition		 Brca1tm1Thl/Brca1tm2Rjbr
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Thl mutation (1 available); any Brca1 mutation (114 available)
Brca1tm2Rjbr mutation (1 available); any Brca1 mutation (114 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor latency ( J:177853 )
• 45 days compared with 68 days in Krastm4Tyj/Kras+ Tg(Ipf1-cre)6Tuv Trp53tm1Thl/Trp53tm1Thl
• however, latency is similar to in Brca1tm1Thl/Brca1tm1Thl Krastm4Tyj/Kras+ Tg(Ipf1-cre)6Tuv Trp53tm1Thl/Trp53tm1Thl




Genotype
MGI:5494462
cn4
Allelic
Composition		 Brca1tm1Thl/Brca1tm3.1Rjbr
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Thl mutation (1 available); any Brca1 mutation (114 available)
Brca1tm3.1Rjbr mutation (1 available); any Brca1 mutation (114 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor latency ( J:177853 )
• as in Krastm4Tyj/Kras+ Tg(Ipf1-cre)6Tuv Trp53tm1Thl/Trp53tm1Thlmice succumb to pancreatic tumors with an average latency of 65 days




Genotype
MGI:5494463
cn5
Allelic
Composition		 Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor latency ( J:177853 )
• mice succumb to pancreatic tumors with an average latency of 68 days




Genotype
MGI:5008634
cn6
Allelic
Composition		 Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
Trp53tm1Thl/Trp53tm1Thl
Tyrc-Brd/Tyrc-Brd
Genetic
Background		 involves: 129/Sv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2Thl mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (240 available)
Tyrc-Brd mutation (8 available); any Tyr mutation (379 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:172585 )
• median survival is 27 days following injection of PDGF and cre compared with 85 days for similarly treated Ptentm1Hwu homozygotes

neoplasm
increased tumor growth/size ( J:172585 )
• following injection of PDGF and cre, tumor growth is increased compared to in similarly treated Ptentm1Hwu homozygotes
increased glioblastoma incidence ( J:172585 )
• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells

nervous system
increased glioblastoma incidence ( J:172585 )
• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
glioblastoma proneural subtype DOID:0050804 J:172585




Genotype
MGI:3603329
cn7
Allelic
Composition		 Trp53tm1Thl/Trp53tm1Thl
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pbsn-cre)4Prb mutation (2 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:100683 )
N
• no prostatic tumors are detected in 9-week old mutants




Genotype
MGI:5315853
cn8
Allelic
Composition		 Huwe1tm1Wgu/Y
Tg(Ins2-cre)23Herr/0
Trp53tm1Thl/Trp53tm1Thl
Genetic
Background		 involves: C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Huwe1tm1Wgu mutation (0 available); any Huwe1 mutation (63 available)
Tg(Ins2-cre)23Herr mutation (1 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:182446 )
N
• mice survive longer than Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:182446 )
N
• diabetic symptoms (serum glucose and insulin levels and glucose intolerance) observed in Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice are improved
hyperglycemia ( J:182446 )
• in fasting mice at 9 months but not as severe as in Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice
• in fed mice at 3, 6 and 9 months but not as severe as in Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:182446 )
N
• islet organization is improved compared to in Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory