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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp53tm1Thl
targeted mutation 1, Thomas Ludwig
MGI:3589921
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ptentm2.1Ppp/Ptentm2.1Ppp
Trp53tm1Thl/Trp53tm1Thl
Tg(Pbsn-cre)4Prb/0 		involves: 129S1/Sv * C57BL/6 * DBA/2 MGI:3603330
cn2
 		Brca1tm1Thl/Brca1tm1Thl
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:5494464
cn3
 		Brca1tm1Thl/Brca1tm2Rjbr
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:5494465
cn4
 		Brca1tm1Thl/Brca1tm3.1Rjbr
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:5494462
cn5
 		Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0 		involves: 129S4/SvJae * FVB/N MGI:5494463
cn6
 		Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
Trp53tm1Thl/Trp53tm1Thl
Tyrc-Brd/Tyrc-Brd 		involves: 129/Sv * 129S4/SvJae * C57BL/6 MGI:5008634
cn7
 		Trp53tm1Thl/Trp53tm1Thl
Tg(Pbsn-cre)4Prb/0 		involves: C57BL/6 * DBA/2 MGI:3603329
cn8
 		Huwe1tm1Wgu/Y
Tg(Ins2-cre)23Herr/0
Trp53tm1Thl/Trp53tm1Thl 		involves: C57BL/6J * CBA/J MGI:5315853


Genotype
MGI:3603330
cn1
Allelic
Composition		 Ptentm2.1Ppp/Ptentm2.1Ppp
Trp53tm1Thl/Trp53tm1Thl
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm2.1Ppp mutation (0 available); any Pten mutation (86 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (235 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:100683 )
• all mutants died by 7 months of age

neoplasm
increased prostate gland tumor incidence ( J:100683 )
• invasive prostatic cancer is seen in all mutants by 10 weeks of age
• average tumor weight is increased 32-fold compared to mutants wild-type for Trp53 and these tumors encompass the entire genitourinary tract and pelvis
• no increase is seen in the number of senescent cells compared to wild-type prostates unlike in mutants wild-type for Trp53
increased carcinoma incidence ( J:100683 )
• by 11 weeks of age invasive adenocarcinoma develops

renal/urinary system
urinary bladder obstruction ( J:100683 )
• bladder obstruction

reproductive system
increased prostate gland tumor incidence ( J:100683 )
• invasive prostatic cancer is seen in all mutants by 10 weeks of age
• average tumor weight is increased 32-fold compared to mutants wild-type for Trp53 and these tumors encompass the entire genitourinary tract and pelvis
• no increase is seen in the number of senescent cells compared to wild-type prostates unlike in mutants wild-type for Trp53

endocrine/exocrine glands
increased prostate gland tumor incidence ( J:100683 )
• invasive prostatic cancer is seen in all mutants by 10 weeks of age
• average tumor weight is increased 32-fold compared to mutants wild-type for Trp53 and these tumors encompass the entire genitourinary tract and pelvis
• no increase is seen in the number of senescent cells compared to wild-type prostates unlike in mutants wild-type for Trp53




Genotype
MGI:5494464
cn2
Allelic
Composition		 Brca1tm1Thl/Brca1tm1Thl
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Thl mutation (1 available); any Brca1 mutation (113 available)
Krastm4Tyj mutation (9 available); any Kras mutation (83 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (235 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor latency ( J:177853 )
• mice succumb to pancreatic tumors with an average latency of 68 days




Genotype
MGI:5494465
cn3
Allelic
Composition		 Brca1tm1Thl/Brca1tm2Rjbr
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Thl mutation (1 available); any Brca1 mutation (113 available)
Brca1tm2Rjbr mutation (1 available); any Brca1 mutation (113 available)
Krastm4Tyj mutation (9 available); any Kras mutation (83 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (235 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor latency ( J:177853 )
• 45 days compared with 68 days in Krastm4Tyj/Kras+ Tg(Ipf1-cre)6Tuv Trp53tm1Thl/Trp53tm1Thl
• however, latency is similar to in Brca1tm1Thl/Brca1tm1Thl Krastm4Tyj/Kras+ Tg(Ipf1-cre)6Tuv Trp53tm1Thl/Trp53tm1Thl




Genotype
MGI:5494462
cn4
Allelic
Composition		 Brca1tm1Thl/Brca1tm3.1Rjbr
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Thl mutation (1 available); any Brca1 mutation (113 available)
Brca1tm3.1Rjbr mutation (1 available); any Brca1 mutation (113 available)
Krastm4Tyj mutation (9 available); any Kras mutation (83 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (235 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor latency ( J:177853 )
• as in Krastm4Tyj/Kras+ Tg(Ipf1-cre)6Tuv Trp53tm1Thl/Trp53tm1Thlmice succumb to pancreatic tumors with an average latency of 65 days




Genotype
MGI:5494463
cn5
Allelic
Composition		 Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (83 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (235 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor latency ( J:177853 )
• mice succumb to pancreatic tumors with an average latency of 68 days




Genotype
MGI:5008634
cn6
Allelic
Composition		 Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
Trp53tm1Thl/Trp53tm1Thl
Tyrc-Brd/Tyrc-Brd
Genetic
Background		 involves: 129/Sv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2Thl mutation (0 available); any Gt(ROSA)26Sor mutation (985 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (86 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (235 available)
Tyrc-Brd mutation (7 available); any Tyr mutation (378 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:172585 )
• median survival is 27 days following injection of PDGF and cre compared with 85 days for similarly treated Ptentm1Hwu homozygotes

neoplasm
increased tumor growth/size ( J:172585 )
• following injection of PDGF and cre, tumor growth is increased compared to in similarly treated Ptentm1Hwu homozygotes
increased glioblastoma incidence ( J:172585 )
• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells

nervous system
increased glioblastoma incidence ( J:172585 )
• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
glioblastoma proneural subtype DOID:0050804 J:172585




Genotype
MGI:3603329
cn7
Allelic
Composition		 Trp53tm1Thl/Trp53tm1Thl
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pbsn-cre)4Prb mutation (2 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (235 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:100683 )
N
• no prostatic tumors are detected in 9-week old mutants




Genotype
MGI:5315853
cn8
Allelic
Composition		 Huwe1tm1Wgu/Y
Tg(Ins2-cre)23Herr/0
Trp53tm1Thl/Trp53tm1Thl
Genetic
Background		 involves: C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Huwe1tm1Wgu mutation (0 available); any Huwe1 mutation (63 available)
Tg(Ins2-cre)23Herr mutation (1 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (235 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:182446 )
N
• mice survive longer than Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:182446 )
N
• diabetic symptoms (serum glucose and insulin levels and glucose intolerance) observed in Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice are improved
hyperglycemia ( J:182446 )
• in fasting mice at 9 months but not as severe as in Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice
• in fed mice at 3, 6 and 9 months but not as severe as in Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:182446 )
N
• islet organization is improved compared to in Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice




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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory