Phenotypes associated with this allele

• Allele Symbol: Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell
• Allele Name: transgene insertion N8, John F Elliott
• Allele ID: MGI:3590083
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	H2-Ab1^b-tm1Gru/H2-Ab1^b-tm1Gru Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell/Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell	NOD.Cg-H2-Ab1^b-tm1Gru Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell	MGI:3687137

Genotype
MGI:3687137

cx1

• Allelic Composition: H2-Ab1^b-tm1Gru/H2-Ab1^b-tm1Gru; Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell/Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell
• Genetic Background: NOD.Cg-H2-Ab1^b-tm1Gru Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:113267 )

N • no mice develop heart block at any age

immune system

immune system phenotype ( J:113267 )

N • mice do not develop cardiac autoantibodies, or diabetes at any age

thyroid gland inflammation ( J:113509 )

increased autoantibody level ( J:113509 )

• mice do not develop cardiac myosin autoantibodies, but 100% develop thyroid autoantibodies by 55 weeks of age

endocrine/exocrine glands

enlarged thyroid gland ( J:113509 )

• 25% of mice with thyroiditis develop thyroid gland enlargement and goiter

thyroid gland inflammation ( J:113509 )

homeostasis/metabolism

increased circulating thyroid-stimulating hormone level ( J:113509 )

• a subset of mice with an enlarged thyroid gland develop thyroid failure with elevated serum TSH levels