Phenotypes associated with this allele

• Allele Symbol: Bach1^tm1Igar
• Allele Name: targeted mutation 1, Kazuhiko Igarashi
• Allele ID: MGI:3590153
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bach1^tm1Igar/Bach1^tm1Igar	B6.129P2-Bach1^tm1Igar	MGI:3718512
hm2	Bach1^tm1Igar/Bach1^tm1Igar	involves: 129P2/OlaHsd * C57BL/6J	MGI:3590336

Genotype
MGI:3718512

hm1

• Allelic Composition: Bach1^tm1Igar/Bach1^tm1Igar
• Genetic Background: B6.129P2-Bach1^tm1Igar

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal vascular smooth muscle morphology ( J:123370 )

• vascular smooth muscle layer is thinner (1226+/-19.3 versus 1840+/-22.5 um² in wild-type mice)

abnormal systemic arterial blood pressure ( J:123370 )

• following ischemic injury and reperfusion, mice do not show a decrease in systolic and diastolic blood pressures as wild-type mice do

muscle

abnormal vascular smooth muscle morphology ( J:123370 )

• vascular smooth muscle layer is thinner (1226+/-19.3 versus 1840+/-22.5 um² in wild-type mice)

decreased cardiomyocyte apoptosis ( J:123370 )

• following ischemic injury and reperfusion, apoptosis of myocardial cells is decreased

homeostasis/metabolism

abnormal response to injury ( J:123370 )

• following ischemic injury and reperfusion, mice do not show a decrease in systolic and diastolic blood pressures as wild-type mice do

• following ischemic injury and reperfusion, heme-oxygenase levels and activities are increased in the left ventricle

• following ischemic injury and reperfusion, infarct size is reduced compared to wild-type mice and wild-type mice treated with hemin

• following ischemic injury and reperfusion, the number of infiltrate cells is smaller

• following ischemic injury and reperfusion, apoptosis of myocardial cells is decreased

• however, treatment with ZnPP, a heme-oxygenase-1 inhibitor, results in an infarct size comparable to that in wild-type mice following ischemic injury and reperfusion

cellular

decreased cardiomyocyte apoptosis ( J:123370 )

• following ischemic injury and reperfusion, apoptosis of myocardial cells is decreased

Genotype
MGI:3590336

hm2

• Allelic Composition: Bach1^tm1Igar/Bach1^tm1Igar
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

normal phenotype

no abnormal phenotype detected ( J:100802 )

• homozygotes are healthy and fertile with no gross abnormalities but express elevated levels of HMOX1