Phenotypes associated with this allele

• Allele Symbol: Pycard^tm1Tno
• Allele Name: targeted mutation 1, Tetsuo Noda
• Allele ID: MGI:3590154
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pycard^tm1Tno/Pycard^tm1Tno	involves: 129S4/SvJae * C57BL/6	MGI:3590347
cx2	Mefv^tm5.1(MEFV)Chae/Mefv^tm5.1(MEFV)Chae Pycard^tm1Tno/Pycard^tm1Tno	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:5007932

Genotype
MGI:3590347

hm1

• Allelic Composition: Pycard^tm1Tno/Pycard^tm1Tno
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased interferon-gamma secretion ( J:100807 )

• IFN-gamma secretion is suppressed in lipopolysaccharide treaded mice that had been previously "primed" with heat-killed Propionibacterium acnes

decreased interleukin-1 beta secretion ( J:100807 )

• Il-1beta secretion is suppressed in lipopolysaccharide treaded mice that had been previously "primed" with heat-killed Propionibacterium acnes

• no Il-1beta secretion by either macrophage or Kupffer cells in response to LPS

• failure to activate procaspase-1 in macrophage in response to LPS

decreased interleukin-18 secretion ( J:100807 )

• Il18 secretion is suppressed in lipopolysaccharide treaded mice that had been previously "primed" with heat-killed Propionibacterium acnes

• no Il18 secretion by Kupffer cells in response to LPS

decreased susceptibility to endotoxin shock ( J:100807 )

• resistant to lethal doses of lipopolysaccharide when "primed" with heat-killed Propionibacterium acnes

Genotype
MGI:5007932

cx2

• Allelic Composition: Mefv^{tm5.1(MEFV)Chae}/Mefv^{tm5.1(MEFV)Chae}; Pycard^tm1Tno/Pycard^tm1Tno
• Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

immune system

immune system phenotype ( J:172117 )

N • mice do not exhibit inflammatory phenotypes observed in Mefv^{tm5.1(MEFV)Chae} homozygotes

decreased interleukin-1 beta secretion ( J:172117 )

• bone marrow CD11b+ cells stimulated with LPS and ATP fail to secrete IL1beta unlike wild-type cells

growth/size/body

growth/size/body region phenotype ( J:172117 )

N • mice exhibit normal growth